The Research On TCM Conpound By Anti-tubeiculosis Medication Treatment Of Liver Damage

Anti-tuberculosis drugs induced liver damage in high incidence, the exact efficacy of modern medicine no hepatoprotective drugs, the use of Chinese medicine compound on the treatment of this disease and achieved good results. In this study, Chinese medicine compound in the treatment of liver injury caused by antituberculosis drugs treating aspects of the law, to clarify the main compatibility prescription used ideas and methods for the clinical treatment of Chinese medicine liver damage caused by anti-tuberculosis drugs for reference.This article mainly from the some aspects of TCM treatment of liver damage caused by anti-tuberculosis drugs were studied.The first part is the theory discussion. Modern medicine fight med tuberculosis medicaments liver injury caused by the research results, by using statistical method, discusses anti-tuberculous drug liver injury caused mainly syndrome, etiology, commonly used therapies and the prescription medication regularly. The results show that patients' clinical symptoms are anorexia, liver discomfort or pain, fatigue, nausea, vomiting, jaundice, abdominal distension, tongue dark purple, moss greasy, pulse fine or strings and abnormal liver function, who are anti-tubeiculosis medication treatment of liver damage; This is that as the main lesion liver and spleen, the TB first, Qi xu and drug toxicity of liver injury is the causes. Damp and hot, Qi yu, blood sluggish are main pathological factors. Liver and spleen are common lesions viscera; The common treatment are Buqijianpi, Shuganliqi, Lishiqingre, Xingxuehuoxue and so on. Notice liver and spleen treatment, evil and positive are both;Prescription form to Spleen, liver and gas as the basic structure, compatibility of clearing away heat and the main drug, taking into account the blood liver, activating blood.Medicine is calm and avoid attack Jun gong Jun fill. Spleen qi to help focus on transportation, common Gancao, Baizhu, Shanyao; Li shi both qing re, common using Fuling,Yinchen,Zhizi;Xing Qi is focus on liver Qi, and by conditioning temper, common using Chaihu Zhike Chenpi; Activating blood instead of expelling blood, common using Danshen and Yujin; Enrich the blood and Rou liver are not nourish tired, common using Danggui, Baishao; With less nourishing Yin liquid,that is different from TB therapies.The second part is the experimental research. Using mice with anti-tuberculosis drugs CCl4 acute liver damage caused by the model, we observe the liver to fight consumptive disease soup for high and low dose group of acute liver damage ALT and AST activity of change and the index of liver. Using mice to maximum dosage were determined to acute toxicity tests. Results: the liver to fight consumptive disease high and low dose group of soup can reduce CCl4 and anti-tuberculous drug acute liver damage caused by mice serum ALT, AST content and index of liver. Mice to give out 225g/(kg-d)for maximum dosage,155 for clinical dosage. Prompt the liver to fight consumptive disease high and low dose group of soup of anti-tuberculosis drugs CCl4 and liver damage caused by the mice have protection. And small toxicity, clinical medication safety and reliability.The last part is showing one case of simultaneous analysis of medical records.