| Objective Herdsmen drinking habits according to set up brick tea fluorosis in rats with chronic aluminum intoxication and low-United lower aluminum fluoride brick tea model,ob-serving and analyzing the aluminum fluoride brick tea on rat body weight,learning and memo-ry,nervous system,blood system,skeletal system Organize the fluoride and aluminum con-tent,explore the brick tea fluorosis United poisoning aluminum pathophysiological mecha-nisms.For the radical Al-tea fluorosis United poisoning and provide a theoretical basis. Methods 4 weeks weanling wistar male rats 24,female 36,one week after raising fitness, randomly divided into 6 groups. The control group(drinking water),pure aluminum group (the amount of aluminum-containing drinking water 159mg/L),pure fluorine group (drinking water fluoride100mg/L),aluminumfluorideUnitedGroup(theamount of aluminum-containing drinking water 159mg/L, fluoride 100mg/L),brick tea group(drinking brick tea water),tea group(drinking tea water).Sub-cage farming,the groups are required for the preparation of drinks only source of drinking water,free diet,the experiment rats with body weight measured every three months;experiment the last two months of learning and memory behavior of their evaluation;executed after the end of the experiment was determined brain somatostatin(SS)content;observation of the brain,liver,spleen,kidney micro-structure;and test blood and serum, kidney,liver,bones,teeth,brain fluorine(F),alumi-num (Al) content. Experimental data obtained from the disability standards in order to have a few bad(X±S)said that the use of statistical analysis software SPSS13.0 treatment,testing the standard of admission a=0.05.Results aluminum can cause weight gain in rats,alumi-num fluoride United than the role of aluminum and the slow but sustained serious;tea can one age weight loss in rats(p<0.05);aluminum can cause learning and memory dysfunction(p <0.05),aluminum fluoride aluminum United than a more serious role(p<0.01),brick tea also can cause learning and memory dysfunction(p<0.05);fluoride,aluminum can cause a decline in the number of SS in hippocampus(p<0.05),aluminum fluoride United than the role of aluminum severe(p<0.01),single-fluoride brick tea than in a serious role(p<0. 01);high concentration of fluoride can improve rats MCV,PLT(p<0.05);Puer tea can re-duce the rat HCT,MCV,MCHC (p<0.05);high concentration of aluminum fluoride can promote the absorption and serum,bones,teeth,brain,liver accumulation. Brick tea can cause bone and teeth,the increase in fluoride content of liver(p<0.05).High concentra-tions of aluminum accumulation in serum,bone,teeth,brain(p<0.05),high concentra-tions of fluoride can inhibit the absorption of aluminum. Brick tea can cause teeth,aluminum content in the liver increased(p<0.05),tea cause kidney,liver aluminum content increased (p<0.05);United Group and the aluminum fluoride pure aluminum rat brain cerebral ede-ma;aluminum fluoride United Group and the emergence of simple renal proteinuria fluoride; aluminum fluoride brick tea group United Group and the small area of liver punctate necrotic foci.Conclusion 1.successfully copied the brick tea fluorosis United Aluminum poisoning rat model.2.aluminum fluoride exist simultaneously,the high concentration of aluminum flu-oride can promote absorption,and high concentrations of fluoride can inhibit the absorption of aluminum.3.fluorine element in the main target organs are targeted bone,teeth,and can cause corresponding damage.Aluminum aimed primarily at the target organ are bones,teeth, brain,can cause growth stunting and learning and memory dysfunction.4.selection of tea in place of an ordinary brick tea could not affect the taste and color of brick,under the premise of the prevention of brick tea fluorosis United poisoning happened aluminum.
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