| Objective1. To analyze the clinical characteristic of persistent truncus arteriosus (PTA) in the hospital patients during the past 10 years, evaluate the therapeutic efficacy and prognosis of PTAs.2. To evaluate the quality of life of PTAs from eight dimensions of PF, RP, BP, GH, VT, SF, RE and MH by using SF-36 scales as measuring tools.MethodsHospitalized PTAs from January, 1999 to December, 2008 were collected from Guangdong General Hospital medical records. The cases that were received and therapied in hospital from January, 1999 to December 2003 were in the first group and in January 2004 to December 2008 were in the second group. Data of gender, age, PTA types, treatment methods, clinical manifestations and auxiliary examination, etc were collected. Statistical analyses were done for the above variables. PTAs were followed-up. UCG and the growth and development outcomes were compared with the normal peer group. 20 cases of in-patients with other etiological factor who were non- heart disease and older than 14 years and had reading ability were chose as the control group. Questionnaire of SF-36 scale were asked and filled. Then data collection, collation and statistical analysis were done. ResultsThere were 65 cases of PTAs hospitalized in Guangdong General Hospital from January, 1999 to December, 2008; male to female ratio was 3.06:1. The median age of hospitalization was 838 days(3-15286days),The cases of PTAs in the first and second five-year cycle were 30 and 35. The cases in the second five-year cycle were increased for 5(16.67%). 27 cases of patients were received the surgical repair and 19 cases were survived. The survival rate was 70.37%. 8 cases were deceased.The mortality was 29.63%.The MPA, AV, RV, LVDd, LVDs and C / T were reduced after surgical repair. LVEF, LVFS were increased after repair. The difference was statistically significant (P <0.05). The cases that tricuspid valve regurgitation occurred before and after repair were 6 and 9. RBBB occurred in 10 cases after repair. 10 years follow-up of the main indicators of growth and development on PTA survivors were: mean height 155.69±13.53cm, mean body weight 45.18±12.57kg,mean chest circumference 69.50±10.00cm.The index of growth and development such as height , body weight , chest circumference ,etc in PTAs were lower than normal urban children, but there was no statistically significant.The scores of the eight dimensions of PF, RP, BP, GH, VT, SF, RE, MH in PTAs were as follows: 83.00±6.75,74.40±9.28,15.00±13.45,45.00±17.16,69.50±11.17,86.25±14.96,40.00±40.98 and 50.00±20.41,and in non-heart disease patients were: 93.25±10.17,75.75±32.44,17.15±24.28,55.75±11.73,65.25±9.25,74.37±15.95,71.66±42.26,66.80±9.00.In PTAs, PF(t=-2.87,P=0.008) and RP(t=-2.22,P=0.035) were lower, but MH (t=-2.16,P=0.040) were higher than the control group. The differences were statistically significant. There were not statistically significant in the dimensions of BP, GH, VT, SF, RE compared with the control group (P>0.05). Conclusions1. The number of hospitalized patients with PTA was increasing. The proportion of males was higher than females, which was similar to the reports from domestic, but higher than the reports from abroad.2. The only effective method of therapy for PTA was surgical treatment. After the surgical repair, the preload, after load and ejection function of left ventricular were improved.3. The followings had the better prognosis among patients without surgical treatment: with no combination of other complex congenital heart malformations, whose pulmonary circulation was supplied by bronchial artery and PTA had aortic collateral.4. SF-36 scale is a universal quality of life scale, which has good reliability and validity. The total score of PF, RP, BP, GH and RE in patients with PTA were lower than the norm of Americans and Chinese. The differences were statistically significant (P<0.05). In the dimensions of VT, SF, MH there were no statistically difference between patients with PTA and the norm of Americans and Chinese (P>0.05).
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