Application And Analyses Of Antibiotics After Pediatric Living Donor Liver Transplantation

Objective: To analyses the experience in the use of antibiotics after pediatric living donor liver transplantation(LDLT) in our hospital, so as to improve pediatric living donor liver transplantation therapy.Methods: Forty two cases were operated for LDLT in our hospital from Jun 2006 to December 2009. Analyses were done retrospectively for the categories and sensitivity of bacterial infection, and summary experience and characteristics in the use of antibiotics after pediatric living donor liver transplantation.Results: A Thrity-three cases among forty-two (78.6%) had bacterial infections after LDLT, the peak of infection is 5~7d after the operation. Infection sites were: respiratory tract in 28 cases, abdominal infection in 20 cases, urinary tract infections in 3 cases, gastrointestinal infection in3 cases; Infected bacteria: Gram-negative bacteria 59 (75.6%), gram-positive bacteria 19 (24.4%); Gram-negative bacteria as Pseudomonas aeruginosa in 14 cases(16.7%), Klebsiella pneumoniae in 12 cases(15.4%), Gram-positive bacterium as Staphylococcus epidermidis in 8 cases(10.3%), feces Enterococcus in 6 cases(7.7%), after the first rule of thumb routine use of antibiotics to prevent infection, then selected according to bacterial infection sensitive to antibiotics; Antibiotics used in combination in 33 cases (76.8%), single agent in 9 cases (23.2%); commonly used antibiotics are: Ceftizoxime, levofloxacin, imipenem and vancomycin, etc.Conclusion: Children living donor liver transplantation higher bacterial infection, respiratory and abdominal infections are common sites; Strengthen surveillance of antimicrobial resistance of bacteria isolated, rational choice based on the sensitivity of pathogenic bacteria antibiotic drugs for treating children after living donor liver transplantation infection and improve the efficacy of the main measures.