Research On The Relationship Between TCM Syndrome Differentiation Of Bronachial Asthma And Changes Of NE, DA And 5-HT

Objective: To investigate the change between bronchial asthma patients' plasma monoamine neurotransmitter and their TCM syndrome differentiation. Methods: Randomly collected 84 cases of bronchial asthma patients from the respiration department in the Affiliated Chinese medicine hospital of Xinjiang Medical University. Divided them into different groups according to TCM syndrome differentiation. The contents of plasma monoamine neurotransmitter were measured by high perfonmence liquid chromatography (HPLC), such as NE,DA and 5-HT. 46 normal people were served as control group. Results: In total clinical cases, the ratio of kidney deficiency and stagnation of phlegm was 46%, the non-kidney deficiency and stagnation of phlegm was 54%(contain the ratio of cold phlegm was 21%, the ratio of heat phlegm was 15%, the ratio of frigiopyretic phlegm was 7%, the ratio of anemophlegmatic phlegm was 11%). The kidney deficiency and stagnation of phlegm mean age is greater than the non-kidney deficiency and stagnation of phlegm(P<0.05). And the two of group didn't present statistical significance in gender(P>0.05). The content of NE and DA in bronchial asthma patients was higher than the normal control group(P<0.05). A significant increase of NE and DA was found in non-kidney deficiency and stagnation compared to kidney deficiency and stagnation (P<0.05), two groups had no statistical significance in 5-HT(P>0.05). Conclusions: (1)Bronchial asthma patients' plasma monoamine neurotransmitter are disordered, asthma can cause the increase of neurotransmitter, or nervous reflex could aggravate symptoms of asthma. (2)Kidney deficiency and stagnation of phlegm was the most common type of bronchial asthma;"The same disease different syndrome, the different syndrome different principle", There is variability in the release of neurotransmitter because of the difference of TCM syndrome differentiation. The lower content of NE and DA in bronchial asthma patients of kidney deficiency and stagnation of phlegm, it is maybe excitability of central nervous system to lower, so the release of monoamine neurotransmitter to be depression. This is maybe a part of biology foundation of"deficiency in origin"in asthma of kidney deficiency and stagnation of phlegm.