To Analyze Correlation Factors Effected On The Outcome Of Chronic HBV Infection

Objective: To analyze gender, family history, HBV-DNA levels, HBeAg states, ever treated with antiviral drugs, case history and age of finding HBV infection were effected on hepatic cirrhosis, hepatic inflammation and decompensated cirrhosis in the process of chronic HBV infection. Methods: Clinical data of 223 CHB patients infected exceed 10 years were retrospective analyzed. Gender, family history, HBV-DNA levels, HBeAg states, ever treated with antiviral drugs, case history, age of finding HBV infection and biochemical markers were observed. The patients were divided into cirrhosis group and non-cirrhosis group, active hepatitis group and non-active hepatitis group, compensation group and decompensation group. T-test was used to identify measurement data,χ2 test was used to identify numeration data and Logistic regression analysis was used to analyze some possible correlation factors associated with the outcome of chronic HBV infection after measurement data were graded. Results: Multiplicity showed that male (P=0.002), family history positive (P=0.002), ever treated with antiviral drugs (P=0.001), HBeAg positive (P=0.019), age of finding HBV infection (P=0.000) and case history (P=0.04) were correlated closely with cirrhosis compared with non-cirrhosis. Multiplicity showed that ever treated with antiviral drugs (P=0.028) and HBV-DNA levels (P=0.000) were correlated closely with hepatic inflammation compared with non-hepatic inflammation. Multiplicity showed that male (P=0.006), family history positive (P=0.042), ever treated with antiviral drugs (P=0.001), age of finding HBV infection (P=0.001), case history (P=0.020) and HBV-DNA levels (P=0.011) were correlated closely with decompensated cirrhosis compared with compensated liver function. Conclusion: Patients with HBV-DNA high levels were related to the development of hepatitis, cirrhosis and decompensated cirrhosis. HBV replication may be suppressed, hepatic inflamation may be relieved, the risk of cirrhosis and decompensation cirrhosis may be decreased by antiviral therapy. Proceeding of HBV infection may be effected by male, family history positive, HBeAg positive, age of finding HBV infection and case history.