The Expression And Clinical Significances Of E-cadherin, KAI1 And BRCA2 In Invasive Lobular Carcinoma Of Breast

Objective: To investigate the expression and clinical significances of E-cadherin, KAI1 and BRCA2 in invasive lobular carcinoma of breast. Methods: 66 cases definitely diagnosed as invasive lobular carcinoma and 30 cases as fibroadenoma were collected. The expression of E-cadherin, KAI1 and BRCA2 was examined by immuno- histochemistry staining (PV-9000). Result: (1) The positive rates of E-cadherin, KAI1 and BRCA2 in invasive lobular carcinoma respectively were 16.67%, 39.39% and 65.15%, and those in fibroadenoma respectively were 100.00%, 93.33% and 90%. There was significant difference between invasive lobular carcinoma and fibroadenoma (P<0.05). (2) The positive rate of E-cadherin in invasive lobular carcinoma was significantly correlated with histopathological grading (P<0.05); and has no correlation with ages, tumor sizes, clinical stage, lymph node metastasis and menopause or not. The positive rate of KAI1 was significantly correlated with ages (P<0.05), and has no correlation with tumor sizes, clinical stage, histopathological grading, lymph node metastasis and menopause or not (P< 0.05). The positive rate of BRCA2 has no significantly correlation with any clinic-pathological significance. The expressions of E-cadherin, KAI1 and BRCA2 were all not correlated with ER and PR. (3) In invasive lobular carcinoma of breast, the expression of E-cadherin was not associated with KAI1 or BRCA2, and the expression of KAI1 has significantly correlation with BRCA2 (P=0.001, r=0.394). Conclusion: The expressions of E-cadherin, KAI1 and BRCA2 are lower in invasive lobular carcinoma and those are not enough to be the metastatic indicators of invasive lobular carcinoma of breast. KAI1 and BRCA2 may has synergistic reaction in invasive lobular carcinoma.