The Impact Of Itopride On Egg, Gastric Emptying Rate, The Concentration Of Motilin Of Patients With Postprandial Distress Syndrome

Objective: To investigate the impact of Itopride on EGG, gastric emptying rate, the concentration of motilin of patients with postprandial distress syndrome.Methods: Subjects were these patients with postprandial distress syndrome who fit on inclusion criteria, 196 cases were selected randomly from consecutive successive hospital outpatients and inpatients to be observed, each patient was tested HP with a 14C breath test, 112 Hp-positive patients were randomly divided into four groups: patients in the first group were received the treatment of hydrotalcite tablet (1.0 Tid) for 4 weeks; Patients in the second group were received treatments of itopride hydrochloride tablet(50mg Tid) and aluminum magnesium carbonate tablet (1.0 Tid) for 4 weeks; Patients in the third group were received the treatment of aluminum magnesium carbonate tablet (1.0 Tid) for 4 weeks, also received the anti-Hp therapy as anti-Hp triple therapy: using bismuth potassium citrate tablet (0.6 Bid), tinidazole tablet (0.5 Bid), amoxicillin capsule (1.0 Bid) for 1 week; Patients in the fourth group were received treatments of these patients in the second group and anti-Hp treatment for a week, as the anti-Hp program was used in the third group. 84 HP-negative patients were randomly divided into two groups: patients in the fifth group were received the treatment of aluminum magnesium carbonate tablet (1.0 Tid) for 4 weeks; Patients in the other group as the sixth group were received treatments of itopride hydrochloride tablets (50mg Tid) and aluminum carbonate magnesium tablets (1.0 Tid) for 4 weeks.Patients in each group were collected fasting blood 2ml centrifuged before and after treatment, samples were stored in -40℃refrigerator; Their motilin were tested; fasting and postprandial EGG was recorded by EGG recorder measurements and Gastric emptying rate were tested by using X ray opaque markers before and after treatment.Results:In four Hp-positive groups: (1) compared with the postprandial / fasting power ratio, reaction area, gastric emptying rate and motilin concentration before and after treatment; The detective results of the second and four groups were statistically significant, but the detective results of the first and the three groups was not statistically significant; (2) Compared with the percentage of gastric dysrhythmia before and after treatment, the detective results of the second group was statistically significant only, and the remaining three groups were not statistically significant.In the two Hp-negative: (1) Compared with the postprandial / fasting power ratio, the reaction area, the rate of gastric emptying and motilin concentration before and after treatment; the detective results of the sixth groups were statistically significant, but the fifth group was not statistically significant. (2)Compared with the percentage of gastric dysrhythmia before and after treatment, the detective results of the two group were not statistically significant.Correlation analysis: (1) difference of four indicators motilin (postprandial / fasting power ratio, the reaction area, gastric emptying rate and the concentration of motilin) before and after treatment had significant correlation with the use of itopride, while the stomach dysrhythmia percentage had no significant correlation with the use of itopride before and after treatment; (2) HP infection and the difference of five indicators before and after treatment had no significant correlation; (3) anti-Hp therapy had no significantly correlated with the difference of the five indicators before and after treatment.Conclusion:(1) Itopride significantly increased postprandial / fasting power ratio, the reaction area, gastric emptying rate, the concentration of motilin of patients with postprandial distress syndrome, and promoted gastric motility effectively; (2) Hp infection and anti-Hp therapy had no significant correlation with gastric dynamics of patients with postprandial distress syndrome.