The Regular Research Of Traditional Chinese Medicine Bianzheng Lunzhi Of Primary Biliary Cirrhosis

Objective:primary biliary cirrhosis (PBC) is an autoimmune disease, in order to carry out destruction of intrahepatic small bile ducts, chronic cholestasis as the main feature. Clinical manifestations of chronic obstructive jaundice and liver enlargement of the spleen, liver failure may appear later with signs of portal hypertension and so on, PBC cause has not been fully clarified, but is known to be an immune disorder regulate disease, its pathogenesis are complex and involve genetic susceptibility, immune system, infection factors and chemical substances. PBC as autoimmune diseases, immunosuppressive agents was first studied and applied, but the kinds of effective immunosuppressive agents are not sure, or adverse reactions were, In particular, long-term use of steroid drugs in patients with osteoporosis will increase the clinical application of a general lack of. UDCA is the U.S. FDA-approved treatment PBC only effective drugs, but UDCA could significantly prolong the survival period and the demand for liver transplantation there are different points of view. Liver transplantation is the preferred treatment of progressive PBC, but because of the liver source, funding, rejection and other factors that limit its clinical application of transplantation. And the liver transplant would be spared of the recurrence of PBC, AMA titer rise. Also occur in patients with symptoms related to PBC. About 10%of patients will require a second liver transplant. Chinese medicine treatment of PBC, can significantly improve the clinical efficacy, the current Chinese medicine for PBC overall research is still in its early stages, the domestic Chinese medicine workers to PBC had a lot of elucidation, but their point of view not yet uniform. Research Based on the above, we have collected in Hubei Province Chinese Medicine Hospital 2006.11-2009.12 hospitalized cases of 63 cases of patients with PBC data were analyzed retrospectively. All 63 cases of patients to the UDCA treatment of Western medicine, Chinese medicine decoction of Chinese medicine by giving oral syndrome differentiation. Observation of their gender, age, TCM syndrome distribution, symptoms and signs, laboratory test results and other changes, as well as between the various card-type symptoms and signs, laboratory test results whether the significant difference in order to explore the treatment of PBC in Chinese medicine identified laws, clinical application so as to provide the basis for Chinese medicine, on the PBC lay the foundation for further understanding.Methods:(1) 63 cases, admission details ask, a detailed physical examination, and improve relevant laboratory examinations, including the three conventions, liver and kidney function, a protein, prothrombin time, a full set of autoimmune hepatitis, the immune ball protein, viral hepatitis markers, liver and gallbladder spleen color Doppler ultrasound (if necessary, make further CT examination).(2) treatment, all patients give UDCA oral, TCM syndrome differentiation given by oral administration of decoction of Chinese medicine in the treatment process, based on their clinical symptoms of the change, addition and subtraction with the card.(3) discharged, detailed record of patient symptoms and signs, and review the three conventions, liver and kidney function and other projects. The above summary of patient data collection, measurement data with a mean±standard deviation (X±S), using computer statistical software SPSS17.0 to t test and X2 test for statistical analysis. Observation of sex, age, differentiation of syndromes, symptoms and signs, laboratory test results and other changes, as well as symptoms and signs among the various syndromes, laboratory test results whether there were significant differences. P<0.05 as significant difference between the boundaries.Results:(!) Basic information on 63 patients, of which 49 cases of female patients (77.8%), male patients 14 cases (22.2%) as a 2:7 ratio of male and female patients; the youngest is 29 years old, the oldest were 79 years, the average age of 57 years of age; found that when the course of the disease in January to 14 years, median 2 years, the average number of days hospitalized for 15 days.(2) TCM Traditional Chinese Medicine by syndrome differentiation type distribution, the distribution of traditional Chinese medicine syndromes Spleen Liver Depression followed by 28 cases (44.4%), hot and humid Accumulation Type 12 cases (19.0%), wet stagnation and blood stasis type in 10 patients (15.9%) liver and kidney in 8 cases (12.7%), spleen deficiency in 3 cases (4.8%), Pi Yang weak in 2 cases (3.2%)(3) The main symptoms and signs, and improvements in the distribution of main symptoms are:fatigue (*), Niaohuang (*), anorexia (*), abdominal distension (*), skin itching, right upper quadrant pain (*), poor sleep; the main symptoms are:skin and mucous membranes yellow dye, shifting dullness (*), splenomegaly, liver palm, lower extremity edema (*), hepatomegaly, abdominal tenderness. Before and after treatment,* P<0.05.(4) comparison of the results of liver function tests of liver function test items include:ALT(*), AST(*),r-GT, ALP, TBIL, IBIL, A, G, Tch.. before and after treatment comparison, treble, *improved significantly (P<0.05)。(5) between the various card-type symptoms and signs, laboratory test results of the comparison.:Damp-Heat Accumulation Type with Niaohuang the most common, fatigue, abdominal distension, anorexia, skin itching in various syndromes occur relatively high frequency. Spleen-Kidney Yang Deficiency is more common to move the dullness, liver depression spleen deficiency type, hot and humid Accumulation Type, damp stagnation blood stasis type and liver-kidney stained skin, sclera frequency is relatively high, Piyang sluggish due to the number of cases compared with type less meaningful conclusions have not observed. Damp-Heat Accumulation Type laboratory test results were higher than those of other card types。Conclusions:(1) PBC more common in female patients, the subjects collected cases, the ratio of 2:7 male and female patients, and the age of onset more than 40 to 70 years old。(2) PBC TCM in patients with liver depression-type main deficiency of the spleen, Accumulation Type hot and humid, damp stagnation and blood stasis type, liver-kidney, spleen deficiency type Pi Yang weak type。(3) PBC patients, Western medicine by UDCA, TCM syndrome differentiation given by oral administration of decoction of Chinese medicine. Its symptoms and signs, laboratory test results, etc. are greatly improved。(4) Damp-Heat Accumulation Type with Niaohuang the most common, fatigue, abdominal distension, anorexia, skin itching in various syndromes occur relatively high frequency. Spleen-Kidney Yang Deficiency is more common to move the dullness, liver depression spleen deficiency type, hot and humid Accumulation Type, damp stagnation blood stasis type and liver-kidney stained skin, sclera frequency is relatively high。Damp-Heat Accumulation Type laboratory test results were higher than those of other card types(5) This experiment also confirmed that, PBC patients with AMA-positive rates are higher.63 cases of cases, AMA (+) 54 cases (86%).