| Objective: Coronary artery disease has become a threat to public health of the major diseases in China with the improvement of people's living standards. Each year, more than one million people in China die from coronary heart disease. Hypertension, hyperlipemia, diabetes, obesity and smoking are considered to be the traditional risk factors for coronary heart disease. In recent years, people began to look for other risk factors which cause coronary heart disease and related. Arterial elasticity and Microalbuminuria are two important indicators of coronary heart disease occurrence and development, and more and more attention has been paid to them. Both of them are hot spots in clinical studies of coronary heart disease. Microalbuminuria is a change signal in vascular reactivity, which not only reflects the early stage of renal vascular and glomerular disease, but also prompts systemic vascular endothelial dysfunction. Microalbuminuria is the window of systemic vascular disease in the kidney's performance, which indicates the changes in the entire vascular system. Microalbuminuria is the most sensitive and pristine indicators for renal damage. Arterial elasticity is related with the generation and development of coronary heart disease. Arterial elasticity could be a risk factor of cardiovascular diseases, and also be a strong factor for predicting the prognosis of coronary vascular disease. Lower arterial elasticity is a sign of cardiovascular disease and it can predict the progress of cardiovascular disease before the occurrence of clinical symptoms. It also involves in the pathogenesis of cardiovascular disease and is related with the death of cardiovascular disease. This study adopts AASI as an index of arterial elasticity. Our study investigates the relationship between AASI and UAER in patients with coronary heart disease, and approaches their function of generation and development in coronary heart disease. The purpose of this study is to provide rationale for the prevention and treatment of coronary heart disease.Methods: A total of 41 patients with coronary heart disease who were inpatients in the 2nd Hospital of Hebei Medical University were selected between April and November 2009, including 29 males and 12 females, with mean age of 58.73±9.35 years old. All subjects had included: (1) Diabetes mellitus; (2) Urinary system disease such as nephritis, Nephrotic Syndrome, urinary system infection; (3) Renal insufficiency; (4) Peripheral Vascular Diseases; (5) Neoplasms; (6) severe arrhythmia; (7) Valvular heart disease. All subjects were diagnosed patients with coronary heart disease by coronary angiography. The information of every patient includes sex, age, body weight, body height, body mass index, cholesterol, triglyceride, the history of smoking and alcohol drinking, and the history of hypertension. Body mass index is calculated as weight/height2 (kg/m2). 24-h ambulatory blood pressure monitoring instrument is used for ambulatory blood pressure monitoring. Using brachial artery with cuff deflation interval, the pressure wave signal in cuff is recorded in these enrolled patients. The diurnal blood pressure is recorded every 30 minutes, and nocturnal blood pressure is recorded every 60 minutes. Diurnal time is set from 6 AM to 10 PM, and nocturnal time is set from 10 PM to 6 AM. Computation of AASI is based on the regression slope of diastolic over systolic BP readings obtained from 24-hour recordings, and AASI is 1 minus this regression slope. Collect all subjects' urine specimens of 24 hours, and then determine the total volume of urine. Take some specimen after mixed fully, and then measure urinary albumin excretion rate (UAER) in endocrine laboratory. Statistic analysis is performed by using SPSS Statistical software. Normality and homogeneity of variance test is used to test all measurement data. Measurement data which obey normal distribution and is continuous variable is expressed as mean±SD, and independent t-test is used for two groups'comparison. Analysis of variance is used for three treatment groups. The non-parametric test is used for the data which do not meet the normal distribution. Linear regression analysis is used for studying relationship between two variables. P<0.05 is regarded as statistical significance.Result: (1) The ambulatory arterial stiffness index in the study population is 0.44±0.17; the age is 58.73±9.35 years old. The UAER is 13.14±9.48μg/min, with 9 individuals in positive group and 32 individuals in negative group. (2) AASI is positively correlated with age (r=0.456,P<0.05). The AASI in women is 0.46±0.14, and the AASI in men is 0.43±0.18. There is no statistically difference between them (P>0.05). There is no correlation between AASI and BMI in coronary heart disease (P>0.05). (3) AASI of three-vessel lesion group is the highest (0.67±0.07), followed by two-vessel lesion group (0.47±0.15). AASI of single-vessel lesion group is the lowest (0.37±0.15). Any two groups of them is statistically different (P<0.05). (4) There is no correlation between AASI and UAER in coronary heart disease (P>0.05). (5) The AASI of UAER positive group is 0.51±0.18, and the negative group is 0.42±0.17. Two samples are not significant different (P>0.05). (6) There are 20 people in single-vessel lesion group; its median and mean rank is 8.8μg/min and 21.85 respectively. There are 17 people in two-vessel lesion group; its median and mean rank is 7.9μg/min and 16.59 respectively. There are 4 people in three-vessel lesion group; its median and mean rank is 25.35μg/min and 35.50 respectively. The number of coronary vascular disease in different branches of the three groups in coronary heart disease is different in UAER, and the difference is statistically significant by non-parametric test (P<0.05).Conclusion: In patients with coronary heart disease, AASI is positively correlated with age and it increases with age. The AASI of the three-vessel disease group is the highest, and the AASI of the single-vessel disease group is the lowest. The UAER of three-vessel lesion group and two-vessel lesion group, and single vessel lesion group, is different. AASI is not associated with UAER in coronary heart disease.
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