Clinical Observation On Treatment Of Azoospermia Due To DAZ Gene Deletion With Yangjing Capsule

Objective:To observe the effects of Yangjing Capsule treatment on azoospermia due to DAZ gene deletion, and discuss the mechanisms.Methods:Forty-eight patients of azoospermia with DAZ gene deletion, were randomly divided into a treatment group(n=28) and a control(n=20). The former treated by Yangjing Capsule (5 pills, tid) and the latter with testosterone undecanoate (40mg, bid). The efficacy was observed after treatment for six months and the inedxes such as semen volume, seminal a-glucosidase enzyme(a-Glu), prostatic acid phosphatase(ACP), fructose in seminal plasma(Fru), gonadal hormone(FSH, LH, T, E2, PRL) were analyzed at 3 months before and after treatment.Results:1. The totaleffective rate was 35.7%(10/28) in the treated group, which was significantly higher than that in the controlgroup,10.0%(2/20, P<0.05). After ICSI/PGD, in treatment group, fertilization number was 34, fertilization rate was 44.7%,5 cases got biochemical pregnancy, biochemical pregnancy rate was 41.7%,3 cases got clinical pregnancy, clinical pregnancy rate was 33.3% and two of live births. While in the control group, fertilization number was 5, the fertilization rate of 35.7%,1 case of biochemical pregnancy, biochemical pregnancy rate was 50.0%, no clinical pregnancy.2. There are significant differences on the average age, bilateral testicular volume and serum FSH values between the effectives and non-effectives in the treatment group(P<0.05).3. Yangjing capsule elevated serum FSH, LH and T levels, had no significant impact on the E2 and PRL, while testosterone undecanoate increased T levels, and suppressed LH levels by the way of the negative feedback.4. Yangjing capsule increased semen volume and the a-Glu, Fru and ACP level in seminal plasma.Conclusion:1. It is treatable for the patients of lower age, larger testicular volume and not too high serum FSH.2. Yangjing capsule is an effective drug on azoospermia duo to DAZ gene deletion. The mechanisms which may act on the hypothalamus-pituitary-gonadal axis, thus promoting the generation of sperm.3.Yang Jing Capsule can also promote the secretory function of epididymis, seminal vesicle and prostate.