| Backgrounds:Migraine is a common clinical, recurrent headache disease, higher incidence rate in women than men, especially in the stage of childbearing age. Recently, a series of studies found the different headache characteristics, anatomical and functional differences in central nervous system between women and men. Although these differences may be the result from many factors, but quite a lot of evidences support sex hormones be the important role. Research data also show that targeted therapy combined with hormonal contraceptives can reduce the frequency of migraine headache and relieve the severity of menstrual related migraine and migraine with aura. Objective:To investigate migraine patients’changes of various hormones levels of the hypothalamus-pituitary-gonadal axis, differences of gonad axis hormones in different types of migraine patients. Relationship between hormone contents of the gonadal axis and clinical characteristics of migraine were also analyzed. Methods:119 patients with migraine headache were collected in Shandong Provincial Hospital headache clinics from Nov.l,2014 to May.l,2015 as case group,42 tension-type headache sufferers with similar age and gender visited hospital in the same period as the case-control group,30 healthy people collected with the same age and gender as the healthy control group. Headache diagnosis based on the ICHD-2 diagnostic criteria, excluded the secondary headaches, made a detailed record of all the basic information and clinical features of the patients. All the research objects complete the measurement of FSH、UH、E2、PRG、To and PRL in our hospital clinical laboratory, GnRH level is measured by radioimmunoassay method. Observe gonadal axis hormone content differences of the 3 groups; Compare the differences of gonadal axis hormone levels between migraine with aura (MwA) and migraine without aura (MWoA), menstrual related migraine (MRM) and menstrual not related migraine (MNrM), hereditary migraine and sporadic type migraine of. And the relevance between gonadal axis hormone levels in migraine patients and migraine characteristics such as course, duration, attack frequency were also analyzed. Hormone levels of men, childbearing-aged women in different menstrual periods, menopausal women were conducted respectively in all the analysis.Results:(1) PRL (P< 0.05) and GnRH (P< 0.01) level in male patients were higher than the healthy controls, PRG was lower than healthy controls (P< 0.01), no difference was found between the TTH group and healthy controls. During follicular phase, To was lower than healthy controls (P< 0.01), PRL, GnRH contents of migraine and TTH patients (P< 0.01) were higher than healthy controls, no difference was found between migraine and TTH group in the female patients; In the luteal phase, E2 and To (P< 0.05) were lower than the healthy controls, PRL, GnRH (P< 0.05) were higher than healthy controls. PRG and To (P< 0.01) were lower than the TTH and healthy controls, PRL (P< 0.05) was higher than the healthy controls, GnRH (P< 0.05) was higher than the healthy control group, but lower than TTH in menopause patients. (2) PRG, PRL in male MwA patients(P < 0.01) were significantly high than MWoA. E2 (P< 0.05) of female MwA in luteal phase was lower than MWoA patients. To of postmenopausal MWoA (P< 0.05) was lower than MwA patients. LH of MNrM patients (P< 0.05) was higher than MRM patients in follicular phase, PRL (P< 0.05) levels was higher than patients with MRM in luteal phase. FSH (P< 0.05) of male patients with hereditary migraine was higher levels than sporadic type. To (P= 0.052) of female patients with hereditary migraine was higher in luteal phase without significant difference. PRG, To (P< 0.05) were lower in hereditary patients after menopause than in sporadic type. (3) In male patients, FSH (r= 0.474) and LH(r= 0.502) were positively related with headache course, PRG (r= 0.399) was negatively correlated with the course, E2 (r= 0.602) was negatively associated with the MIDAS score. Female patients during follicular phase, FSH (r= 0.325) was positively related with headache course, E2 was positively correlated with duration of headache (r= 0.374) and VAS score (r= 0.331), negatively related with MIDAS score(r= 0.334). During luteal phase, E2 (r= 0.772) and PRG (r= 0.464) were negatively correlated with MIDAS score, FSH (r= 0.631) and LH(r= 0.713) were positively related with MIDAS score. E2 (r= 0.674) was negatively correlated with the frequency of migraine attacks, PRG (r= 0.768) and To (r= 0.889) were negatively correlated with MIDAS score in postmenopausal patients.Conclusions:Gonadal axis abnormalities were common in E2, To, PRH, PRL and GnRH in migraine patients. Differences were obvious between MwA and MWoA, MRM and MNrM, genetic and sporadic type migraine. Changes of gonadal axis hormones were associated with headache characteristics, and the correlation with MIDAS score is the most prominent. Gonadal axis anomalies may be the outcome of disease progress combined with individual genetic differences.Objective:To investigate migraine patients’changes of various hormones levels of the hypothalamus-pituitary-adrenal axis, differences of adrenal axis hormones in patients of migraine with aura and migraine without aura. Relationship between hormone contents of the adrenal axis and clinical characteristics of migraine were also analyzed. Methods:119 patients with migraine headache collected in Shandong Provincial Hospital headache clinics from Nov.l,2014 to May.l,2015 as case group,42 tension-type headache sufferers with similar age and gender visited hospital in the same period as the case-control group, and select the 30 healthy people with the same age and gender to the patients as the healthy control group. Headache diagnosis based on the ICHD-2 diagnostic criteria, exclude the secondary headaches, made a detailed record of all the basic information and clinical features of the patients. All the research objects completed the measurement of Cor and ACTH in our hospital clinical laboratory, CRH level is measured by radioimmunoassay method. Observe adrenal axis hormone content differences of the 3 groups. Compare the difference of adrenal axis hormone content between MwA and MWoA. And the relevance between adrenal axis hormone levels in migraine patients and migraine characteristics such as course, duration, attack frequency were also analyzed. Results:(1) Cor and CRH (P< 0.001) levels of migraine and TTH patients were significantly higher than that of healthy people, no obvious difference between patients with migraine and TTH; ACTH (P< 0.001) was significantly lower in migraine sufferers than healthy people. (2) CRH was significantly higher in MwA patients than that of MWoA patients (P= 0.011), no difference in the Cor and ACTH levels.(3) Cor level in migraine patients was positively related with the course of disease, correlation is more obvious in female patients (r= 0.259).Conclusions:Adrenal axis hormone anomalies showed the increase in Cor and CRH, decrease in ACTH; there were differences in adrenal axis hormones between MwA and MWoA patients; changes in adrenal axis may be related to the course of the disease. |
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