Hs-CRP,IL-6,ox-LDL Changes In Patients With CHD After PCI And Correlation Study With TCM Syndrome

Objective:To observe hs-CRP,IL-6,ox-LDL changes in patients with CHD after PCI,To discuss the influence of PCI on Inflammatory response and lipid peroxidationo Research the pathogenesis of Inflammatory response and lipid peroxidation,and the relationship with TCM Syndrome.Find the clinical value of hs-CRP,IL-6,ox-LDL in the severity of coronary artery lesion and Syndrome Differentiation by TCM。Methods:All patients had coronary angiography in hospital,71 cases CAG positive,67 cases of them were carried out PCI. (man 46 cases, women 21 cases,61.42±10.94 old age); 27 CAG negative (man 13cases,womenl4cases,61.28±10.84 old age). Patients were grouped through TCM syndrome Differentiation and Lesion severity. ELISA is used to measures the hs-CRP, IL-6 and ox-LDL level before and after treatment. T test technique be used in Statistical analysis to them.Results:1. The hs-CRP and IL-6 levels of The corporeal syndrome group is significantly increased than deficiency syndrome group (P<0.05)2. The hs-CRP level of phlegm -turbid retention syndrome group is significantly different to Qi- deficiency Heart syndrome group,Yang-deficiency of heart and kidney syndrome groupand Yin-deficiency of heart and kidney syndrome group (P<0.05)3. The hs-CRP levels of preoperative and postoperative PCI group are significantly increased than control group (P<0.05).At the same time, we find that the hs-CRP level of postoperative PCI group is significantly increased than the preoperative PCI group. (P<0.05)4. The IL-6 levels of preoperative and postoperative PCI group are significantly increased than control group (P<0.05).And the ox-LDL level of the PCI group is significantly different to the control group(P<0.05).5. The hs-CRP and IL-61evels of PCI group increased with the increasing of the severity of coronary artery lesion degree. There were significant difference between multiple vessel disease and single vessel disease in hs-CRP and IL-6 level. (P<0.05)Conclusion:1. There are correlations between the TCM Syndrome Differentiation of coronary heart disease and the hs-CRP,IL-6 levels. This can be used as theobjective bases to discriminate the TCM Syndrome.2. The ox-LDL level of the CHD patients has no correlations with TCM Syndrome Differentiation and the severity of coronary artery lesion degree.3. There are correlations among the hs-CRP,ox-LDL,IL-6 level of the CHD patients. This can be used to diagnose and prognose CHD.4. The IL-6,hs-CRP level of the CHD patients has significant correlations with the severity of coronary artery lesion degree. This can be used to estimate the everity of coronary artery lesion degree...