Syndrome Differentiation Acupuncture Regulation Of Estrogen And 5-HT Levels In The Treatment Of Perimenopausal Syndrome Application

Theoretical research:Menopausal Syndrome (MPS) is refer to a group of clinical complicated symptoms during perimenopausal and postmenopausal time. It is a commen disease in the climacteriumic women.Its clinical symptoms are complicated and may apper many somatopsychic changes.So the patients suffer from it very much.Many new ideas and therapeutic methods have been brought forwad and great achievement has been acquired.This article has collected the development of MPS in Traditional Chinese Medicine as well as Western Medicine are expounded.It can be clinical reference of MPS.Pathophysiology,HRT of modern medicine and the treatment of TCM are importantly produced.Then,the writer gives some of his thinks of disease.The Problem of nowdays have also been issued .Experimental research:Objective:To observe the the effect of acupuncture in Regulation Dialectics Estrogen and 5-HT In The Menopausal SyndromeMethods:Preparation of 80 perimenopausal rats,the rats were divided into acupuncture group,estrogen group,control group and blank control group. Acupuncture and hormone replacement therapy in the regulation of estrogen and 5-HT levels on perimenopausal rats,four groups of indicators on statistical analysis and comparison.Results:1.Serum E2 levels in ovariectomized rats compared with control group,acupuncture group was significantly lower estrogen( P< 0.01);2.Acupuncture group than in the estrogen group compared with serum E2 levels of the control group,acupuncture group,estrogen group was not statistically significant (P>0.05),close to the level of blank group3.Castration serum brain serum 5-HT,as well as LDL,TG levels significantly lower than the control group (P<0.01),compared with the acupuncture group, estrogen group decreased (P<0.01)4.Acupuncture group taught serum estrogen rat brain 5-HT,as well as LDL,TG levels than the acupuncture group,estrogen group was not statistically significant (P>0.05),close to the level of blank groupConclusion:Compared to hormone replacement therapy,acupuncture treatment will be more stable control of estrogen levels and 5-HT levels.Thus in the treatment of climacteric syndrome in the process of reducing cardiovascular disease incidenceClinical research:Objective:To make acupuncture can improve the treatment of climacteric syndrome patients with perimenopausal syndrome provides clinical evidence that lipid metabolism.Method:1.On 144 patients with climacteric syndrome were randomly divided into acupuncture group,73 patients were estrogen group,71 cases were treated.2.The two groups before and after treatment in patients with sex hormone and lipid levels Observation.Results:1.Acupuncture and estrogen treatment of menopause syndrome were obtained good effect. Which acupuncture group improved 80.82% of the patients achieved disease improvement standards Kupperman score,estrogen group 87.32% of patients achieved improvement of improvement condition Kupperman score standard, modified Kupperman score improved in both groups were not significantly different when compared (P>0.05);2,after taking Dan orange preparations,SOD markedly effective in 2 cases,effective cases of 24,4 cases,markedly effective rate of 6.7% was 80%,total effective rate was 86.7%; MDA markedly one case,effective 27 cases and ineffective in 2 cases efficiency was 3.3%,efficiency 90%,total effective rate was 93.3%,t test all show P<0.05.2.Before and after treatment the acupuncture group FSH,LH level decreased,E2 levels increased,changes are very significant. Before and after estrogen treatment group FSH,LH levels decreased,E2 levels increased. Change is also very significant. FSH levels decreased compared: acupuncture group and control group no significant difference between,P>0.05. LH levels fell comparison: Acupuncture and no difference between the estrogen group,P>0.05. E2 increased the level of comparison: the acupuncture group and no difference between the estrogen group, P>0.05.3.Acupuncture group after treatment,increased levels of HDL-C,LDL-C levels decreased,the difference was statistically significant. After treatment,the estrogen group increased HDL-C levels,LDL-C levels decreased,the difference was statistically significant. 2 groups after treatment compared,HDL-C levels increasedcompared: acupuncture group and no difference between the estrogen group,P> 0.05.Decreased LDL-C levels compared:acupuncture group and no difference between the estrogen group,P>0.05.2 before and after treatment TC,TG change was no significant difference,P>0.05.4.Acupuncture can improve hot flashes,sweating,sensory disturbances,irritability symptoms,insomnia,urinary tract infection symptoms,the difference was statistically significant.Estrogen group can improve hot flashes,sweating,sensory disturbances,insomnia,irritability,urinary tract infection symptoms,the difference was statistically significant. Acupuncture group between the two groups on the hot flashes sweating,sensory disturbances,insomnia,irritability symptoms, urinary tract infection symptoms better than the estrogen group,no significant difference,P>0.05.Conclusion:Acupuncture can improve the climacteric syndrome E2 levels and HDL-C levels and lower FSH,LH levels,LDL-C level,adjust the climacteric syndrome in patients with lipid metabolism,lipid metabolism such adjustments on the role of prevention fat,cardiovascular disease occurrence has a positive meaning.