Study Of Plasma Visfatin And Related Factors In MHD Patients

ObjectiveThe current study was performed to determine the levels of plasma visfatin in patients with maintenance hemodialysis(MHD),examine the possible correlations with plasma lipids,CRP,ALB, renal function and so on.provide theorctical suoppot for further therapy,to reduce the long-term complications and improve the the quality of life.MethodsSelected 40 patients with hemodialysis, chronic renal failure without dialysis patients with uremia of 30 cases, all are in line with the sixth edition of selected patients with chronic renal failure uremia within the scientific diagnostic criteria. All selected patients without acute infection within two weeks; not occurred within three months of cardiovascular adverse events (acute myocardial infarction, unstable angina, cerebrovascular accident, peripheral vascular thrombosis, etc); three months without a significant surgery; no blood disease, severe liver disease, cancer. And except for diabetes, connective tissue disease, rheumatic diseases. All patients with dialysis time greater than or equal to six months were given bicarbonate dialysis, low molecular weight heparin,4 hours per dialysis,3 times a week dialysis, blood flow of 200-220ml/min, dialysate flow rate 500ml/min, dialysate temperature 37℃, CA-HP130 Baxter dialyzers or NiproFB-130 use are one-time, dialysis machines for the Fresenius 4008S. Collection of all clinical and laboratory indicators selected:age, gender,, plasma levels of visfatin, C-reactive protein, liver function, kidney function, blood lipids and Calcium and other laboratory parameters. In healthy non-hospital population of 20 cases were randomly selected as the control group. The above data entry computer, using spss13.0 for statistical analysis. Data are shown as mean±SD.Multiple mean comparison with single factor analysis of variance and LSD test; variance with Games-Howell when incomplete test; visfatin correlated with other indicators used to analyze the Person correlation test, multi-related factors were analyzed by Logistic multiple regression analysis method. Significance was defined as a p value less than 0.05.Results1.MHD patients, CRP, serum phosphorus, phosphorus product, TG, LDL, atherogenic index was significantly higher than the control group;albumin, calcium, HDL lower than the healthy control group. The difference was statistically significant (p<0.05).2. MHD plasma visfatin levels in patients than in healthy controls, the difference was statistically significant (p<0.05). 3. MHD patients visfatin level was negatively correlated with albumin (r=-0.464, p <0.05).4. MHD expression levels of visfatin in patients with C-reactive protein were positively correlated (r=0.575,p<0.01).5. MHD expression levels of visfatin in patients with TG, atherosclerosis index were positively correlated (r=0.420,0.386, p value less than 0.05) and negatively correlated with HDL (r=-0.335,p<0.05).6. MHD group multiple regression analysis showed that, C-reactive protein plasma visfatin level is the most significant factors, followed by TG, the last to albumin.The regression equation was Y (visfatin)= 232.815+15.368 (CRP)+36.786 (TG)-3.042 (albumin).ConclusionPlasma visfatin levels in MHD patients is significantly higher, between men and women the level of plasma visfatin was no gender difference. The existence of MHD patients with lipid metabolism, micro-inflammation and malnutrition. As the MHD plasma visfatin levels in patients with MHD lipid metabolism, micro-inflammatory state is closely related to nutritional status, and multiple regression analysis, CRP, TG, albumin plasma visfatin level is the most significant factor. Therefore, the level measured visfatin evaluation of MHD patients may become the body and health risk prediction of cardiovascular complications in a meaningful indicator.