Infection In Systemic Lupus Erythematosus: A Clinical Characteristic Analysis

To find out the clinical features of infection in systemic lupus erythematosus and risk factors of infection,and make sure the influence of these factors on patients;Based on their clinical characteristics and the risk factors,we can provide scientific basis for development of appropriate nursing interventions.According to the 1997 revised American College of Rheumatology diagnostic criteria for SLE,we collect 156 cases of clinic service and hospitalization from December,2008 to September,2009,then to analyze data.To collect and collate clinical and laboratory data of SLE patients.The clinical data include gender,age,course of illness,hospitalization or not,in-patient days,SLE Disease Activity Index,system damage (such as kidneys,hematological damage,etc) and drug use:including the application of immunosuppressive agents,antibiotics usage,cyclophosphamide treatm-ent and hormone dosage.Laboratory indicators:routine blood test,liver and kidney function,ESR,C-reactive protein,24h urinary protein,immunoglobulin G,immunoglob-ulin A,immunoglobulin M,complement 3,complement 4, anti-double stranded DNA quantification,associated infection serological indicators and the nature,location and so on.Follow-up approach to outpatient mainly,small letters or telephone.We analyzed by SPSS 15.0 statistics software,using ofχ2 test,t test derived clinical features of infection in patients with systemic lupus erythematosus.And we used logistic multiple factor regression analysis to found out the risk factors.Then we analyzed every factor by x2 test,made sure the relationship between different ranges of the factors and intolerance.1.Of 156 cases,there were 55 cases(35.26%) and 76 episodes of infections(48.72%), 18 cases with two episodes of infections(32.73%).Pulmonary and Urinary tract were the main infection site.The main pathogen was gram-negative bacillus.2.There was significant difference in patient's age,duration,SLE combined system damage,hospitalization days,SLE Disease Activity Index of clinical data(P<0.05). There was significant difference in the combination of two or more immunosuppressi-ve agents,broad-spectrum antibiotic use,cyclophosphamide and total daily dose of ho-rmones in drug cases(P<0.05).3.There was significant difference in leukocyte,serum albumin,serum creatinine, complement 3,C-reactive protein,erythrocyte sedimentation rate,24h urine protein level,anti-double stranded DNA quantification(P<0.05).Infection in patients with white blood cell counts,ALB, C3 were lower than non-infected patients,while serum Cr,24h urine protein level,C-reactive protein,erythrocyte sedimentation rate,anti-dsDNA quantification level was increased compared with non-infected patients.4.Univariate Logistic regressions showed course of the disease,SLE combined hematological damage,SLE with renal damage,multi-system damage,hospitalization time,complement 3,anti-double stranded DNA quantification,24h urinary protein,SLE Disease Activity Index,cyclophosphamide total amount,hormone daily dose,2 weeks before the application of broad-spectrum antibiotics,immunosuppressive agents used≥2 species,respectively correlated with infection.5.Multivariate regressions showed hospitalization time,complement 3,24h urinary protein,2 weeks before the application of broad-spectrum antibiotics,hormones daily dose,total dose of cyclophosphamide were independent factors for infection in patients with SLE.Pulmonary was the main infection site.The major pathogen is Gram-negative bacteria.Hospitalization time,24h urinary protein,2 weeks before the application of broad-spectrum antibiotics,hormones daily dose,total dose of cyclophosphamide were independent risk factors for infection of SLE.We should take effective nursing intervention to reduce the incidence of infection in patients with SLE.