The Relationship Between Lipoprotein Lipase Ser447Ter Gene Polymorphism And Cerebral Infarction In The Elderly

Objective To explore the relationship between the lipoprotein lipase Ser447Ter gene polymorphism and cerebral infarction in the elderly.Methods This was a case-control study, which enrolled 196 cases with cerebral infarction in the elderly and 193 elderly incerebrovascular disease controls.The genotype and allele frequencies of LPL Ser447Ter gene polymorphism were assayed by polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP).The cerebral infarction patient were strictly diagnosed according to revises conference in the national fourth session of cerebrovascular disease.The basic document object of study was collection through questionnaire interview.Results The Ser447Ter genotype and allele distribution in the cerebral infarction group studied was CC85.20%,CG14.28%,GGO.5% and C 92.34%, G 7.66% respectively; The distribution in control groups was CC 82.90%, CG 16.58%, GG 0.5% and C 91.19%, G 8.81% respectively. There was no significant difference in Ser447Ter allele and genotype distribution between the cerebral infarction group and the control group (P>0.05).There was non-significance difference was detected in blood pressure level, blood lipids level between various genotypes (P>0.05).Cerebral infarction multi-factor regression equation indicated primary hazard factors including smoking history, diabetes history and family history.Conclusion1,Ser447Ter gene polymorphism is not significantly associated with cerebral infarction in elderly.2,Ser447Ter gene polymorphism is not significantly associated with blood lipids level, blood pressure level in elderly.