Maternal And Fetal Outcomes In Pregnant Patients With Systemic Lupus Erythematosus

Objective The objective of this study was to determine the safety,pregnancy outcome and effect of offspring in pregnant patients with systemic lupus erythematosusMethods Fifty-nine patients with sixty-two pregnancies which were evaluated retrospectively from 1999 to 2009 in our hospital divided into two groups:selective pregnancy(group A)and nonselective pregnancy(group B).The pregnancy outcomes,fetal outcomes, and lupus activity during pregnancy were compared between the two groups.The children of the SLE patients were followed up.Result There were 43 selective pregnancies (group A) and 19 nonselective pregnancies(group B).Of the group A pregnancies, lupus activity occurred in 10 pregnancies(23%), and 35 (81%) resulted in live births,7 resulted in low birth weight infants and 7 resulted in premature delivery. In group B, lupus activity exacerbation occurred in 16 pregnancies(84%), and 13 (68%) resulted in pregnancy loss,6 resulted in live births which were all low birth weight infants. The rates of disease activity and pregnancy loss in group B were higher than thoese in group A (P<0.05).22 children were followed up without SLE patient. However, six children have antinuclear antibody positive titer of 1:80. Of 22 children, one child was suffering from ventricular septal defect.Conclusion Both selective and non-selective pregnancy may adversely effect maternal and fetal outcome, but patients with selective pregnancy have better outcomes either in the lupus flare or maternal and fetal outcomes compared with those with nonselective pregnancy.