Detection And Clinical Significance Of Plasma Protein Z Level In Patients With Coronary Heart Disease

Objective:To investigate the alteration of plasma protein Z levels in patients with CHD and its relationships with risk factors of CHD and the severity of coronary atherosclerosis (defined by Gensini score system)Methods:Plasma protein Z levels were measured by ELISA in 66 patients with coronary heart disease (CHD) which were confirmed by coronary angiography (CAG) and 22 controls with normal CAG findings. CHD group was divided into A (G≤30), B (30 70) groups according to the Gensini scores. The correlations of protein Z levels between traditional risk factors of CHD and Gensini scores were analyzed.Results:The mean plasma protein Z level was lower in CHD group than in controls(715.65±287.13ng/ml vs 1049.19±266.32ng/ml, P<0.05). Mean plasma protein Z levels of A, B and C group were 838.55±300.34 ng/ml,664.44±281.29ng/ml and 609.82±218.18ng/ml respectively, which had a trend to be declining gradually. Mean plasma protein Z levels were significantly lower in group B and group C than in group A (P<0.05), while there was no significant difference between group B and group C(P>0.05). In CHD group, plasma protein Z levels was significant inversely correlated with Gensini scores (R=-0.292, P=0.018). Putting CHD group and control group together, we found that plasma protein Z levels was significant inversely correlated with hs-CRP levels (R=-0.262, P=0.02). Mean plasma protein Z level was lower in smoking subgroup than in no smoking subgroup (710.75±253.18ng/ml vs 885.24±356.75ng /ml, P<0.05). There was no significant relationship between plasma protein Z levels and lipid profiles such as LDL, HDL, TC and TG.Conclusion:Mean plasma protein Z level was significantly decreased in CHD group, Plasma protein Z levels were inversely correlated with the severity of coronary atherosclerosis and hs-CRP. Smoking could induce the decrease of plasma protein Z levels. These results showed that protein Z levels may reflect the severity of coronary atherosclerosis, inflammation reaction and smoking could affect plasma protein Z levels in a certain extent.