The Effect Of Simvastatin On Radius Fracture Healing In Rabbits

Objective:To investigate the effect of Simvastatin on repairing rabbits radius fracture. And to provider basic theories and experiments' criterions for further studies and clinical applications of Simvastatin in repair fracture, also to afford the new thought and method for clinic fracture treatment.Method:Thirty-six health rabbits were distributed to A,B,C three groups at random, twelve each. A is blank control group; B is BMP-2 control group and C is simvastatin experimental group. Each rabbit was randomly cut off 3 mm of one radius bone to build a standard fracture model,.The blank group were given normal saline by gastric perfusion and injected normal saline in bone fracture location. The BMP-2 control group were given normal saline,but injected BMP-2 in bone fracture location. And the simvastatin experimental group were given simvastatin by gastric perfusion. After 2,4,8 weeks,4 rabbits in each group were killed to evaluate whether they have significant differences of bone healing according to general observation,radiograph, bone density test, biomechanical test and pathological section.Results:General observation:the gross observation showed that in the aspect of osteotylus grow and fracture healing, B,C two groups were better than A group at all the same time; and there is no significant difference between B and C group.Radiograph:X-ray picture showed that in the aspects of osteotylus and recanalization of bone marrow cavity, B and C groups are better A group; and there is no significant difference between B,C two groups.Bone Density test:the result of bone density test showed that:at week 2 and week 4, both B and C groups are superior than A group, there is significant difference (P<0.05).furthermore; when at week 2, B group is superior than C group,with significant difference (P<0.05); when at week 4, there is no significant difference between B and C group (P> 0.05).At week 8,A group is superior than B and C groups, with significant difference (P<0.05), And no significant difference between B and C groups (P>0.05)Biomechanical test:It's demonstrated that B and C group are superior A group,and there is significant difference (P<0.05).and also there is no significant difference between B and C group (P>0.05).Histology examination:It's indicated that the growth of collagen fiber, chondrocyte and bone trabecula were earlier in the C and B groups compared with the A group.Conclusion:â‘ Simvastatin can promote bone growth.â‘¡Simvastatin can promote rabbit fracture healing.