| [Objective] 1.To established the prediction equations of normal lung function for shanghai at the present stage, and expected to verified the value of the earlier one. 2.To determinate the reference range of FEV1/FVC to prediction value. 3.To determinate the reference range of VC, FVC, FEV1,FEV1/FVC, PEF, V75,V50, RV, FRC,TLC and RV/TLC.[Methods] Carrying out epidemic study in people for health examination and presurgical patients who received pulmonary function test in PFT laboratory of Zhongshan hospital between Jun,2009-Feb,2010.Subjects were included if they had all of these following criteria:(1)18.5 kg/m2≤BMI<25kg/m2;(2) Age≥18;(3) Deal with general physical labor,and no system of physical exercise history; (4) Without cardiovascular disease and and endocrine, metabolic diseases; (5)Without chronic cough, sputum, dyspne, and no respiratory tract infection within 2 weeks; (6) with normal chest imaging; (7) In line with the investigators to complete the questionnaire;(8) Spirometric values that did satisfy the quality criteria for acceptance or reproducibility. By age group, selected 240 subjects of lung function were completely normal,men and women of all 120 cases; selected 120 subjects of lung function were basi-normal,men and women of all 60 cases.Recorded and analyzed the general conditions and pulmonary function test results. To established multiple regression equations of all lung function indices, Calculate the prediction value, known as the (prediction value)new; according to the normal prediction value of lung function in Shanghai currently, known as the (prediction value)zhongshan. Comparison of the correlation of two expection values.Calculate the average of these [(prediction value)new-(prediction value)zhongshan]/(prediction value)zhongshan, expected to value the difference of two degrees, to validate the chronergy. And calculate the critical value of lung function. To determinate the reference range of FEV1/FVC to prediction value.[Results](1)by age group:In addition to FRC than the other 12 lung function was found in indices and significant correlation between age.Among them, VC,FVC,FEV1,FEV1/FVC,PEF,V75,V50,TLC,DLCO and KCO were decline with age; RV and RV/TLC were increased with age.(2) By sex group:Found that men's VC, FVC, FEV1, PEF, V75,V50, RV, FRC,TLC,DLCO were higher than female; RV and RV/TLC were the opposite. The differences were statistically significant (independent samples T test, P<0.01).Only the KCO was no gender difference (independent samples T test, P=0.405).(3) multiple regression equation of 240 cases whose airway are completely normal (equation 1):13 lung function indices, in addition to RV/TLC and KCO than the other eleven were significantly associated with sex; in addition to TLC than the other twelve were significantly associated with age; in addition to FEV1/FVC, PEF and RV/TLC than the other ten were significantly associated with height; but only FEV1/FVC, RV,FRC, RV/TLC, DLCO and KCO these are significant correlations between weight.The formula one was found in a comparison with the previous formula:Prediction equations of two groups of lung function, (prediction value)new and (prediction value)zhongshan, respectively related to:VC 0.979,FVC 0.978,FEV1 0.987,FEV1/FVC 0.971,PEF 0.908,V750.981,V500.989,RV 0.971,FRC 0.978,TLC 0.991 and RV/TLC 0.999。P<0.001.Differences in degree results:VC,FVC,FEV1/FVC,PEF,V75,V50,FRC and RV/TLC,these variation are small (less than 5%);However, FEV1,RV, TLC were large variation, more than 5%;In particular, RV's variability reached 14.55%. The statistics of the lung function prediction value that under "absolutely normal lung function" subjects does not conform to the actual situation, the results are really much difference.(4) multiple regression equation of 360 cases whose airway are basi-normal (equation 2):VC=-2.725+0.679(sex)-0.019(age)+0.039(H)+0.008(W)FVC=-3.091+0.702(sex)-0.020(age)+0.044(H)FEV1=-1.653+0.564 (sex)-0.022(age)+0.033(H)FEV1/FVC= 99.121-0.138(age)-0.147(W)PEF=-0.287+2.249(sex)-0.026(age)+0.039(H)+0.026(W)V75=-0.338+1.784(sex)-0.018(age)+0.043(H)V50= 0.836+0.572(sex)-0.027(age)+0.025(H) RV=-2.806+0.194(sex)+0.011 (age)+0.027(H)-0.011(W) FRC=-2.447+0.537(sex)+0.037(H)-0.017(W) TLC=-5.222+0.878(sex)-0.005(age)+0.061(H) RV/TLC=14.981-1.883(sex)+0.248(age)+0.101(H)-0.171(W) DLCO=5.206+4.314(sex)-0.144(age)+0.098(H)+0.082(W) KCO= 9.346-0.026(age)-0.031(H)+0.025(W)13 lung function indices, in addition to FEV1/FVC and KCO than the other eleven were significantly associated with sex; in addition to FRC than the other twelve were significantly associated with age; in addition to FEV1/FVC than the other twelve were significantly associated with height; in addition to FVC,FEV1,V75,V50 and TLC than the other eight were significantly associated with height.The formula one was found in a comparison with the previous formula:Prediction equations of two groups of lung function, (prediction value)new and (prediction value)zhongshan, respectively related to:VC 0.985,FVC 0.981,FEV1 0.989,FEV1/FVC 0.968,PEF 0.966,V750.967,V500.975,RV 0.963,FRC 0.980,TLC 0.981 and RV/TLC 0.989.P<0.001.Differences in degree results:all of these variation in lung function indexes were less than 5%:VC-0.3%,FVC 0.7%,FEV14.7%,FEV1/FVC 2.4%,PEF-4.0%,V75-1.4%,V50-4.3%,RV-5.0%,FRC-2.2%,TLC-3.9% and RV/TLC-2.0%.The statistics of the lung function prediction value That under "the normal and basi-normal lung function" subjects does not only realistic, but the results are not significantly different.(5) calculated the medical reference range of the lung function indices bu using the 360 cases whose are airway basi-normalVC(P5)=-2.2830+0.6908(sex)-0.0170(age)+0.0349(H)FVC(P5)=-2.4015+0.6495(sex)-0.0186(age)+0.0359(H)FEV1(P5)=-3.7289+0.2952(sex)-0.0178 (age)+0.0416 (H)FEV1/FVC(P5)=101.9235-0.1437 (age)-0.1175(H)PEF(P5)=-4.4650+1.6350 (sex)-0.0300 (age)+0.0675 (H)V75(P5)=-2.4090+0.9802 (sex)-0.0181(age)+0.0487 (H)V50(P5)=-2.6144+0.2889 (sex)-0.0237(age)+0.0373 (H)RV(P2.5)=-2.4370+0.0076 (age)+0.0237 (H)-0.0124 (W)RV(P97.5)=-2.0777+0.4506 (sex)+0.0085 (age)+0.0319 (H)-0.0267 (W)FRC(P2.5)=-3.9882+0.5178(sex)+0.0509(H)-0.0480(W) FRC(P97.5)=-7.3340+0.0460(sex)+0.0772(H)-0.0173(W)TLC(P2.5)=-3.4285+0.8561 (sex)-0.0086 (age)+0.0451 (H)TLC(P97.5)=-8.2587+0.8633 (sex)-0.0991(age)+0.0393 (W)RV/TLC(P2.5)=11.5332+0.2584 (age)RV/TLC (P97.5)=7.0284-4.2573(sex)+0.2471(age)+0.2803(H)-0.3511 (W)DLCO(P5)=19.4639-0.1056(age)KCO(P5)=8.9675-0.0236(age)-0.0388(H)+0.0333(W)(6)The lower limit normal of FEV1/FVC%pred is 92%.[Conclusion](1)The ratio of 2:1 with normal lung function and basi-normal of subjects composed of people with the facts.(2) The chronergy of previous prediction equations in shanghai is Satisfying, still Apply to the current population.(3) The results of lung function is expected to in keeping with the present value of the actual situation. We can refer to the results obtained in this study as the normal lower limit(LNN)or the normal two-sector criterion in the absence of medical reference range for lung function(4) Our study found that The lower limit normal of FEV1/FVC%pred is 92%. We can use the data to testing whether there were obstructive ventilatory defect in the clinical.
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