Analysis Of Prognostic Parameters In De Novo Adult Acute Myeloid Leukemia With T(8;21)

The balance translocation between chromosome eight and twenty-one [t(8;21) (q22;q22)] is one of the most common aberrant changes in patients with acute myeloid leukemia (AML). AML with t (8;21) composes 6% of adult de novo AML, and is be usually grouped as the favorable type. However, only 50-60% of t (8;21) AML patients could be cured. There might The heterogeneity of this kind of leukemia might be existed, and then it is important to discover its prognostic parameters and to adopt individualized therapy. There are many factors having been reported to be related with adult t (8;21) AML prognosis, but most of them were focused on one or a few of them. Fifty-six adult de novo AML patients with t(8;21) were enrolled in this study, and the information of their clinical features, cytogenetics, immunophenotype, gene mutations and treatment were collected. The outcomes of overall survival (OS) and disease-free survival(DFS) were analyzed with the above parameters.Firstly, we analyzed the factors related to the OS of the patients by one variable analysis and found that high initial white blood cell counts on the diagnosis of the leukemia, gene mutations (including FLT3, KIT and TET2 gene mutation), CD56 strong expression and high AE9a expression were associated with shorter OS. On the other hand, complemented with loss of a sex chromosome and high dosage Ara-C (HD Ara-C) consolidation after complete remission might be related with longer OS. Then, we made multivariable cox regression analysis with these factors. The result showed that FLT3/KIT/TET2 gene mutations and HDAC were the most important independent factors for OS.The same method was used to analyze the related factors for DFS. The possible determinants of DFS were firstly sorted out by one variable analysis, and then analyzed by using of multivariable cox regression analysis. The results were shown that HDAC and high white blood cell counts on the initail diagnosis of the disease were the most important independent factors for DFS.Based on our research, we could conclude that FLT3/KIT/TET2 gene mutations and HD Ara-C chemotherapy were the most important independent factors for OS while HDAC and high white blood cell counts on the initial diagnosis of the disease were the most important independent factors for DFS.