Expression And Signification Of PKCδ And E-cadherin In Cervical Intraepithelial Neoplasia And Cervical Squamous Cell Carcinoma

Objiective:To investigate the Expression of PKCδand E-cadherin in Cervical Intraepithelial Neoplasia(CIN) and Cervical squamous cell Carcinoma(SCC). Their correlations to clinicopathologic features ofClN and SCC were analyzed.Methods:We detected the expression of PKCδand E-cadherin in normal cervical epithelium(35 cases), CIN(CIN128cases, CIN2 34 cases, CIN3 17 cases) and SCC (31 cases) by means of immuno-histochemical method.Results:(1) The positive rate of PKCδin normal cervical epithelium, CIN1, CIN2, CIN3(including carcinoma in situ) and SCC were 66.8%, 50.0%,44.1%,35.3%,29.0%respectively. All of these data had significant statistical difference(p<0.05)。The positive rates of PKCδin the those in CIN1,CIN2 Were higher than CIN3, but without statisfic difference(p>0.05)。The expression of PKCδwere no correlation with grade of CIN(p>0.05)(2) The positive rate of E-cadherin in normal cervical epithelium, CIN1, CIN2, CIN3(including carcinoma in situ) and SCC were 85.7%,75%,44.1%,41.2%,25.8%respectively, All of these data had significant statistical difference(p<0.05), The positive expression of E-cadherin in the those in normal cervical epithelium were compared with CIN2, and compared with CIN3,CIN1 were compared with SCC, these data had statisfic difference(P<0.05), The expression of PKCδwere negatively correlated to the grade of CIN(p<0.05).(3) Expression of PKCδwere positively correlated to E-cadherin expression in CIN(P<0.05), but without statisfic difference in SCC(P>0.05)Conclusion:(1) Expression of PKCδdecreased with progression of cervical disease, PKCδparticipate with the process of malignant trans-formation in the cervix from normal cervical to SCC。(2) Expression of E-cadherin decreased with progression of cervical disease, E-cadherin participate with the process of malignant trans-formation in the cervix from normal cervical to CIN, to SCC at last。(3) Expression of E-cadherin is negative correlation with the increase grade of CIN。(4) There was a positive correlation between PKCδwith E-cadherin in CIN。...