CYP1A1 And GSTM1 Polymorphisms And Lung Cancer Risk In Non-smoking Women

Background and Objective:Lung cancer is the major cause of cancer-related death. Recently, the rise in lung cancer morbidity among women accompanied by a decrease among men. Smoking is the overwhelming cause for lung cancer, but it can't explain lung cancer in non-smokers. To study the correlation of polymorphisms of CYP1A1 MspI and GSTM1 null genotype independently and in combination with the risk of nonsmoking lung cancer in females. A multiplicative interaction between exposure to cooking oil fumes and CYP1A1 also GSTM1 polymorphisms on risk of lung cancer was evaluated.Methods:160 female nonsmoking patients with primary lung cancer and 160 controls were selected on the basis of a case-control study. PCR-RELP and PCR was used to detect the distribution of CYP1A1 MspI and GSTM1 genotypes respectively. The correlation of these genes and cooking oil fumes with the sensibility to lung cancer was analyzed.Results:There was a significant difference in the frequencies of cooking oil fumes exposure between cancer cases and controls; but no statistical difference of CYP1A1 MspI polymorphisms between the two groups. The combination of CYP1A1 polymorphisms and cooking oil fumes significantly increase the risk of lung cancer. The frequencies of GSTM1 null genotype was significant difference between cancer cases and controls (P<0.05). The risk of lung cancer was higher in those with the GSTM1 null genotype and the OR was 1.697 (95%CI was 1.090-2.640,P=0.019). Individuals with both GSTM1 null genotype and exposure to cooking fumes have a higher risk of cancer than those with only one of them, the OR was 3.617 (95%CI was 1.899-6.891,P=0.000). The combination of the above two genes were significantly increasing the risk of lung cancer.Conclusion:1,Cooking oil fumes exposure was a risk factor for nonsmoking lung cancer in females;2,The combination of CYP1A1 genotype and cooking oil fumes significantly increased the risk of female lung cancer;3,GSTM1 null genotype was associated with risk of lung cancer in nonsmoking females. The combination of GSTM1 null genotype and cooking oil fumes significantly increased the risk of female lung cancer;4,The combination of GSTM1 and CYP1A1 genetic polymorphisms significantly increase the risk of lung cancer.