The Relationship Between The Condition Of Hypoxia And Prognosis Of The Patient With Renal Clear Cell Carcinoma (RCCC)

Objective:To explore the relationship between the condition of hypoxia and prognosis of the patient with renal clear cell carcinoma (RCCC).Methods:To evaluate 116 patients with RCCC who had received nephrectomy. The expression of HIF-la protein in cancer tissue of 116 cases was examined by Streptavidin-Biotin Complex (SABC) immunohistochemistry. The overall survival were analyzed; the relationship to clinicopathological variables, including the presence of chronic pulmonary disease, the positive rate of HIF-1αprotein, smoking history and hemoglobin level were evaluated by the the Kaplan-Meier method.Results:The positive rate of HIF-la protein in the patients with chronic pulmonary disease was higher than that of patient without chronic pulmonary disease, respectively (P=0.021). The median survival time was 60 and 75 months in patients with and without chronic pulmonary disease, respectively (P=0.034). The median survival time was 65 and 80 months in patients with and without positive HIF-1αprotein, respectively (P=0.041). In addition, the hemoglobin level was a significant variable for overall and disease specific survival, respectively (P=0.000). As a result of the analysis, the hypoxemic hypoxia was a prognostic variable for progression to RCCC.Conclutions:1. Chronic pulmonary disease may aggravate the condition of tumour hypoxia.2. The prognosis of the patients with chronic pulmonary disease is worse than that of patient without chronic pulmonary disease.3. Our findings strongly implicate hypoxia as a factor that contributes to a poor prognosis in patients with RCCC.