Clinical Study Of Naoxue-Shutong Oral Solution On Vascular Dmentia

Purpose:To observe the clinical efficacy and safety that we treat vascular dementia (VaD)by the treatment of naoxue shutong oral solution(NXS), compared with another treatment by Oxiracetam capsules (ALXT),and to provide scientific basis for clinical application of NXS.Method:1.According to the diagnostic criteria for vascular dementia published by the World Health Organization of the United States Institute of vascular dementia (DSM-IV),and the NINDS-AIREN diagnosis criteria, Mini-Mental State Examination (MMSE),the patient agreed to standards into line with Those cases,the inclusion of the study of 73 cases, all the patients are divided into two groups:the treatment groupe 35 cases and control group 38 cases.2. Treatment group (n= 45)treated with NXS 20 ml,two times daily, control group (n= 28)treated with Oxiracetam capsules two tablets three times daily,used 8 consecutive weeks,one month follow-up meeting.3.Observation two groups before and after treatment, cognitive functions,and symptoms related to Chinese medicine tongue,pulse changes,the average Blood Flow Velocity of carotid artery and Vertebral Artery changes,drug use before and after a monthly record of regularly completing clinical Observation table.4. Statistical treatment:measurement data using t tests, numeration data using chi square tests, ranked data used Ridit analysis.Result:1. Efficacy analysis:treatment group(n=35) treated VaD, MMSE efficacy: clinical recovery 3 cases, excellence 5 cases, effectiveness 17 cases, and inefficiency 10 cases. total effective rate 71.42%; Chinese medicine Syndrome efficacy:clinical recovery 4 cases, excellence 8 cases, effectiveness 15 cases, and inefficiency 8 cases. total effective rate 77.14%; control group (n= 28) treated VaD, MMSE efficacy:clinical recovery 3 cases, excellence 4 cases, effectiveness 22 cases, and inefficiency 9 cases. total effective rate 76.31%; Chinese medicine Syndrome efficacy:clinical recovery 0 case, excellence 2 cases, effectiveness 14 cases, and inefficiency 22 cases. total effective rate 42.10%; The MMSE efficacy of treatment group have no significant difference in statistical treatment compared with the control group (P> 0.05).The TCM Syndrome efficacy of treatment group have significant difference in statistical treatment compared with the control group (P<0.05). Which showed that both remedies have similar total effectiveness in MMSE,and in TCM Syndrome efficacy NXS is superior to ALXT.2. The related TCM Syndrome integration:Integration of treatment group have highly significant difference after therapy,(P<0.01), integration control group have significant difference after therapy,(P<0.05),the comparison of the two groups have significant difference after therapy (P<0.05).Which showed that treatment group is superior to the control group.3. The integration of intelligence rating scales (MMSE,HDS):Integration of treatment group have highly significant difference after therapy,(P<0.01), integration of control group have highly significant difference after therapy,(P <0.01); the comparison of the two groups have no significant difference before and after therapy (P>0.05); Which showed that both remedies can Increase the patients'integration of MMSE and HDS.4. The integration of Activity of daily living(ADL):Integration of treatment group have highly significant difference after therapy,(P<0.01), integration of control group have highly significant difference after therapy,(P<0.01); the comparison of the two groups have no significant difference before and after therapy (P>0.05); Which showed that both remedies can decrease the patients'integration of ADL.5. Transcranial doppler (TCD) test the cerebral blood flow velocity of internal carotid arteries and vertebral artery:The cerebral blood flow velocity of treatment group have highly significant difference after therapy,(P<0.05), The cerebral blood flow velocity of control group have no significant difference after therapy,(P>0.05); the comparison of the two groups have significant difference before and after therapy (P>0.05) Which showed that NXS is superior to ALXT in increasing the cerebral blood flow velocity.6. NXS treated VaD In TCM Syndrome, the blood stasisdue to qi deficiency type is superior to other types. Which showed that the significance of dialectical treatment by tranditional Chinese medicine.Conclusion:The observation on Chinese medicine naoxue shutong oral solution, showed that it has positive and safe effect in treating VaD, which can enhance the total effect, improve the patients'congnition and activities of daily living, and ameliorate the related TCM syndrome, improve the patients'life quality. All above indicated that NXS is one of the effective medicine in treating mild and moderate VaD,and it is worthy to be popularized in clinic.