| Objective: The research which observing the impact of tuberculosis(TB) infection on the efficacy of inhaled glucocorticoids on children have provided the basis of purposive TB infection for adjuvant treatment of asthma in children.Methods: Outpatients with pediatric asthma in the Anhui provincial hospital was selected, including tuberculosis infection or tuberculin purified protein derivative (TB-PPD) skin test negative asthmatic children, aged less than 5 years old into the A group , older than 5 years old into the B group; Asthmatic children with tuberculosis infection were enrolled as the observation group, TB-PPD skin test-negative were enrolled as the control group. A group of children were treated with the Spacer inhaled fluticasone propionatem, in the initial therapy, the use of low-dose fluticasone a day 100 ~ 200μg, and then according to the level of asthma control to upgrade or downgrade the treatment; B group of children were given budesonide and formoterol fumarate powder for inhalation, a dose of 80/4.5μg, morning and evening, once the suction. During treatment ,children with respiratory infections, then added with anti-infection treatment ;children with acute attacks of asthma, added use Ventolin Aerosol treatment, serious condition, then added oral treatment with prednisone. the observation group were combined tuberculosis infection, according to the program plus isoniazid treatment of 6 to 9 months, part of the children added rifampicin for 3 months. All children's lung function was measured before treatment, three months, six months, using the German JAEGER produced MASTER SCREEN PAED pulmonary function instrument. By comparing the use of emergency mitigation drugs, systemic hormones, as well as the total number of respiratory tract infections, emergency room, hospitalization frequency of clinical indicators, as well as tidal volume (VT), ratio of time to peak tidal expiratory flow and total TE (TPTEF / TE), ratio of expiratory volume at peak tidal expiratory flow and total VE (VPTEF / VE), forced expiratory volume in one second (FEV1), peak expiratory flow (PEF) and other lung function indicators in the observation group and the control group to observe the impact of tuberculosis infection on the efficacy of inhaled glucocorticoids on children with asthma.Results: 120 cases of asthmatic children were enrolled as group A, of which the observation group 62 cases, male 28 cases, female 34 cases, maximum age 51 months, minimum age 6 months, the average age (31.09±15.12) months, the average weight (14.02±5.14) kg. asthma in mild persistent was 45 cases, asthma in moderate persistent was 17 cases; 58 cases of the Control group, male 31 cases, female 27 cases, maximum age of 50 months, minimum age 8 months, the average age (27.70±14.03) months, the average weight (13.40±5.24) kg. asthma in mild persistent was 43 cases, asthma in moderate persistent was 15 cases.It was no significant difference in gender, age, asthma severity classification between the observation group and the control group (P> 0.05). 59 cases of asthmatic children were enrolled as group B,of which the observation group 32 cases, male 17 cases, female 15 cases, the largest age of 11.2 years, minimum age 5.0 years, mean age (7.1±1.7) years old, average weight (23.72±5.6) kg , asthma in mild persistent was 22 cases, asthma in moderate persistent was 10 cases; 27 cases of the Control group, male 13 cases, female 14 cases, the largest age of 10.9 years, minimum age 5.2 years, mean age (7.3±1.6) years old, average weight (24.26±5.79) kg, asthma in mild persistent was 18 cases, asthma in moderate persistent was 9 cases. in gender, age, asthma severity classification,the observation group and the control group was no significant difference (P> 0.05). datas in group A and group B have shown that the Ventolin and Prednisone are at lower dosages in the observation group after three months and six months, the difference was statistically significant (P <0.05);frequency of respiratory tract infection and emergency in three months are no significant difference between the two groups (P> 0.05), after six months ,the difference was statistically significant (P <0.05), frequency of hospitalization was no significant difference between two groups (P> 0.05);after three months , VT, TPTEF / TE, VPTEF / VE have increased in observation groups, but contrasted with the control group,the increase was no significant difference (P> 0.05), after treatment for six months, the difference was statistically significant (P <0.05). Conclusion: (1) The TB infection can increase the efficacy of inhaled glucocorticoids on children with asthma. the need withβ2-receptor agonists and systemic hormone is significantly less than the total amount of non-tuberculosis infection in children with asthma .this shows that TB infection can reduce the use of drugs and systemic hormones and It's conducive to control asthma.(2) The TB infection in children with asthma increase the efficacy of inhaled ICS therapy, the number of respiratory tract infections and the need with emergency treatment to be significantly lower than non-tuberculosis infection in children with asthma, indicating TB infection have an increase of efficacy of inhaled ICS therapy, reducing the probability of asthma in children develop to critical state such as the incidence of adverse events.(3) The TB infection in children with asthma inhaled ICS therapy,the improvement in lung function is better than non-TB infection in children with asthma, indicating that TB infection is conducive to inhalation of ICS therapy to restore lung function in asthmatic children and can be better achieve the treatment of asthma.
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