| Objiective : Henoch-schonlein Purpura(HSP),the orther name is Henoch-Schnlein syndrome ,Often involving the skin, joints, gastrointestinal tract, the kidney, renal damage in Henoch-Schonlein Purpura in the most serious, not only affecting the prognosis of the HSP, is also a major cause of chronic renal failure in children. This study collected a large number of cases of children with Henoch-Schonlein Purpura, on its influence factors of renal damage may occur for statistical analysis, and influencing factors of summary HSPN, we provide a basis for clinical work early judgments occur in renal damage.Methods: Collection May 2005 ~2010 years May stay at Henan University of science and technology of the first affiliated hospital of Pediatrics 110 confirmed cases as of HSP in children with primary and recurrence,The 12 clinical parameters were selected for research and analysis : Gender,age,incentives,living,residence of recurring seasonal,rash,abdominal pain,gastrointestinal bleeding,joint symptoms,angioneurotic edema,increased WBC count,PLT counting rises ,self-made table, records of the relevant data.We use SPSS17.0 software and analysis related statistical data,χ2analysis and logistic regression analysis, respectively.Result:1,There were 67 boys and 43girls in the 110 patients,the ratio of boy to girl is 1.56:1. < 7years old is 35 cases, 75 have been aged≥7. 60 cases of children with first (54.5%) ,50 cases of children with recurrent (45.5%)2,73 children in winter and spring (66.4%), 78 children in village with (70.9%), 32 children in cities and towns (29.1%).3,The primary symptoms: all the sick children with Purpura, accounted for 100%, merged abdominal pain 71 cases, which occurs renal damage of has 52 cases, (73.2%); appears joint pain 57 people cases, occurs renal damage of has 33 people (57.9%); Purpura merged has digestive road bleeding of has 28 cases, occurs renal damage of 24people (92.3%), has 50 cases in children with are has appears continued sexual rash, occurs renal damage of has 40 people (80.0%), Purpura merged vascular neural sexual edema of in children with has 64 people, occurs renal damage has 38 people (59.4%). Newly diagnosed high peripheral white blood cells when there were 69 people, kidney damage has occurred 46 (66.7%), 74 people diagnosed higher peripheral platelet, 52 cases of renal damage (70.2%)4,Incidence and clinical characteristics of renal injury: 72 cases of 110 cases occur in children with renal damage (65.5%). 15 cases of simple hematuria (20.8%); 35 cases of pure protein (48.6%); hematuria with or without the 3 cases of nephrotic syndrome (4.2%); nephritis syndrome 7 people (9.7%); hematuria associated with proteinuria 26 people (36.1%)5,Single factor analysis ofχ2 results: covariates X3 (over 7 years of age, P=0.011,OR=1.451); X6 (abdominal pain, P=0.021,OR=1.444); X7 (gastrointestinal bleeding, P=0.009,OR=3.167); X9 (recurrent rash, P=0.003,OR=2.111) and related kidney damage, a statistically significant (P<0.05), Predisposing factors, regional, seasonal, gender and joint symptoms, angioneurotic edema, peripheral white blood cell count, number of platelets in peripheral blood were all no correlation with renal damage, no statistically significant (P>0.05).6,Multivariate logistic regression analysis: only one covariate abdominal pain, into the model, statistically(P=0.025,OR=11.400,95%CI=1.349-96.35), is an independent risk factors of renal damage occurred, and recurring skin rashes, gastrointestinal bleeding, and over 7 years of age has no connection with renal impairment, no statistically significant.Conclusion:1,repeated skin rashes, gastrointestinal hemorrhage, with more than 7 years of age, occurrence of severe abdominal pain and renal damage are closely related.2,serious abdominal pain are independent risk factors of renal damage occurred.
|
PDF Full Text Request