| Toricellia angulata Oliv. var. intermedia (Harms) Hu is the root or flower of Toothedleaf Torricellia of Cornaceae, used as a folk medicine in Hubei province for surgical trauma,fracture,rheumatic arthritis,blood stasis and tabes, puerperal lumbago, chronic enteritis, diarrhoea and tonsillitis. Toricellia angulata Oliv. with its excellent effect is widely used to treat rheumatic arthritis in Enshi of Hubei province, and it have an extensive perspective of development.During our investigation of the chemical constituents of this plant, thirteencompounds have been isolated from the petroleum ether, n-BuOH-soluble porti-ons in the 95% ethanol extract. On the basis of spectral analysis or direct co- chromatographies with authentic samples, twleve of them were identified as Di-(4,7,8-trihydroxy-3,5-dimethoxyl phenylpropyl )-9-ether (1, new compound), Stigmasterol (2), a-3,4,5-tetrahydroxy benzeneacetic acid (3), Stigmasta-5,11- dien-3β-ol (4), 22,23-dihydrostigmasterol (5),β-daucosterol (6),26,27-dinorchol-esta-8,14-dien-3β-ol (7), Palmitic acid (8), Octadecanoic acid(9),α-D-glucopy-ranose (10),β-D-glucopyranose (11), 4-hydroxy-3,5-dimethoxyl benzaldehyde (12). The compound 1 was a new compound, compound 3 was isolated from nature plant for the first time and compounds 1, 2, 3, 7, 12 were isolated from thisplant for the first time.Compounds 1, 2, 5, 6, 7, 13 were studied var experiments of immunological activity related to the creation of rheumatic arthritis—Con A-induced cell proliferation of rats splenocytes. Compared with the control group, those compounds have immunological inhibiting effect obviously on Con A-induced cell proliferation of rats splenocytes(P < 0.05).
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