Effect Of Surgical Trauma On Human Oral Mucosal Epithelial (OME) Cell Apoptosis And Proliferation And Its Clinical Application

Objective: To evaluate the effect of surgical trauma on human oral mucosal epithelial (OME) cell, we studied the OME cell apoptosis and proliferation in different groups of patients.Methods: OME cells from patients with breast conserving surgery (10), breast cancer patients with radical surgery (13), were collected and analyzed by sub-G1 method and Ki-67 method. Statistical analysis of different groups, pre-operation and post-operation groups was performed.Results: In pre-operation group, there is no significant difference in the age, sex and nutritional status between breast conserving surgery and radical surgery groups in which OME cell apoptosis rates were 27.51﹪±0.61﹪, 27.33﹪±0.53﹪, P=0.669, respectively and proliferation rates were 15.98﹪±0.36﹪,16.04﹪±0.55﹪, P=0.122. In post-operation group, there is also no significant difference of OME cell apoptosis (27.01﹪±0.46﹪,27.36﹪±0.50﹪, P=0.466) and proliferation (16.25﹪±0.25﹪,16.24﹪±0.64﹪, P=0.285) between breast conserving surgery and radical surgery groups.Conclusion: Surgical trauma has no effect on the OME cell apoptosis and proliferation status in vivo.