The Theory And Clinical Research Of YiQiJianPi On Immunity-reconstruction In AIDS Patients

1 ObjectiveObserved in patients before and after treatment of AIDS symptoms, signs, points change, quality of life impact. Indicators of T cell activation in peripheral blood CD4 + T lymphocytes, CD8 + T lymphocytes, CD4/CD8, CD4 + CD45RA, HIV viral load and IL-2, IL-10, TNF and other cytokines at different time points of change. Of the side effects on immune function, for in-depth study of Chinese medicine for HIV / AIDS impact of immune reconstitution to provide clinical basis.2 MethodStrictly meet the test requirements of the AIDS screening 60 patients were already taking HAART drugs, based on randomly divided into two groups of 30 cases. Anti-HIV group were given two sides (AZT +3 TC + NVP) + Chinese and anti-HIV group side (AZT +3 TC + NVP). Two groups of patients were in the treatment of the first 0,3,6, months, signs of change in clinical symptoms, the CD4 + T lymphocytes, CD8 + T lymphocytes, CD4/CD8, CD4 + CD45RA, viral load testing, while the first month safety index 0,6 blood, urine, X ray, electrocardiogram, liver function, kidney function measurement.3 ResultsIn the combination therapy group and the control group were initial symptom total score of 20.37±3.98 and 22.1±6.04 (P> 0.05); three months were 13.30±4.12 and 15.70±5.07 (P <0.05); 6 months was 3.46±2.34, respectively, and 12.10±4.13 (P <0.01), total score of symptoms and signs HAART was better than the control group. Carlo Minkowski integral combination therapy group were in each month after treatment than the control group (P <0.05). In the combination therapy group and the control group starting CD4 + T lymphocyte count was 371.70±82.93 and 338.40±77.73 (P> 0.05); three months after 414.33±81.77 and 360.63±77.01; six months 476.40±87.50 and 408.80±78.87 (P <0.05) were significantly different. CD8 + T lymphocyte count, starting at 1144.10±280.84 and 1154.20±350.36 (P> 0.05); three months to 1309.90±307.52 and 1133.50±265.43 1424.50±425.10 for the six months and 1225.70±279.17 (P < 0.05) were significantly different. CD4/CD8, CD4 + CD45RA no difference between the two groups (P> 0.05), HIV viral load in two groups of patients before and after treatment group were compared between the groups were <500copies/ml. Before and after treatment between the two groups safety index (urine routine, X ray, electrocardiogram, renal function and blood glucose, blood lipids) were not statistically different.4 ConclusionSpleen Qi decoction of Chinese medicine can improve clinical symptoms and signs of AIDS and improve the quality of life; on the percentage of T lymphocytes had no effect, but the effective increase in patients with CD4 + T lymphocyte count, and enhance the patient's immune function; Chinese and Western medicine Combined inhibition of viral replication did not affect the role of HAART; not found on the cell factor had significant effect.