The Change Of TNF-α, Hb And Its Effects On Ventricular Remodeling In Patients With Congestion Heart Failure

Background Congestive heart failure is the finally result of hypertension,coronary heart disease,diabetes and so on.As the development of living standards and medical level enh -ancement,the diagnosis,treatment and research of CHF is gradually developing.Ventricu -lar remodeling is the internal cause of heart failure.The researches of Neuroendocrine hormone, cytokines, cell apoptosis are gradually concerned in occurrence,development of CHF and Ventricular remodeling.Tumor necrosis factor alpha is a kind of cytokines produced by activated macrophages,has extensive biological activities.Including antitumor activity, immunoregulatory activity.It also play a part in inflammation and tissue damage. Hemoglobin is the main component of erythrocyte,is a protein responsible for carrying oxygen in highly advanced beings living, is an important clinical indicator.If the level of an adult male,s hemoglobin under 120g/l or adult women,s hemoglobin under 110g/l,we call that anemia.The above two kinds of material gradually draw people's attention on the occurrence and evolution of congestie heart failure.Objective and Methods To study the changes of the level of tumor necrosis factor-α(TNF-α) and hemoglobin(Hb),as well as the effects of the changes on ventricle remodeling,left ventricular ejection fraction(LVEF),left ventricular mass index (LVMI), mean wall stress(MWS) in patients with congestion heart failure(CHF).121 cases of CHF were eligible in this study, and the level of TNF-αand Hb were measured by radioimmun -oassay;The left ventricular ejection fraction( LVEF) was measured by Echocardiography to evaluate the heart function,and left ventricular mass index( LVMI) and mean wall stress (MWS) were calculated.Thereafter,The patient of heart failure were divided into the ane -mia group and non-anemia group on basis of Hb, observing the influence of TNF-α,Hb, LVMI,MWS and LVEF,and 27 healthy subjects served as the control group.Results The level of TNF-αis higher in the CHF patients than that in controls,the level of Hb is lower than those in the control group (P<0.01). They are higher and lower with the deterioration of cardiac function respectively.In CHF patients,there is a positive relation between the level of TNF-αand LVMI,MWS,a negetive relation between the level of TNF-αand LVEF,Hb.At the same time,a positive relation between the level of Hb and LVEF, a negetive relation between the level of Hb and LVMI,MWS.The level of TNF-α, LVMI ,MWS of Anemia group significantly higher than the non-anemia group, while the level of LVEF obviously lower than the non-anemia group.Conclusions TNF-αand Hb involved in the development process of CHF ventricular remodeling.The increase of TNF-αand the reduce of Hb accelerate the deterioration of cardiac function,at the same time can reflect the occurrence and development of ventricu -lar remodeling to some extent.