| Objective To observe the pattern of corneal neovascularization after the rabbit corneal was infected by fungous. To explore the relationship between the corneal neovascularization and prognosis of fungal keratitis in rabbit eyes.Methods We select seven healthy New Zealand white rabbits to make animal models of fungal keratitis. The changes of rabbit eyes were observed with slit lamp microscope. The progression of fungal ulcer of rabbit eyes were recorded at different time. Pathological and ultrastructural examination were taken at 3,7,15,30 days after the formation of fungal ulcers.Results Heavier inflammation was observed 1 day and 3 days after the formation of fungal ulcers. There are great deals of revascularizations around the peripheral cornea at 7th day. The conjunctival congestion was reducing and corneal ulcer was not improved with the release of corneal neovascularization from the 15th day. At the 30th day, there is less of eye inflammation and a small amount of peripheral corneal neovascularization. Pathological examination showed: At the 3rd day after the formation of fungal ulcers, there was the pathology of severe inflammation, angiotelectasis and no neovascularization. The corneal neovascularization formed at the 7th day. The inflammation limited and there are mature neovascularization at the 15th day. The neovascularization reduced at the 30th day. Ultrastructure observation: There is ultrastructure change of typical inflammatory at the 3rd day and the 7th day after the formation of fungal ulcers. The fungal hyphae can still be seen in the stroma at the 15th day, but much less than before. The corneal epithelial cells nucleus and organelles are abnormalities. The performance is mild inflammation at 30th day and there is no fungal hyphae.Conclusion 1.Rabbit eyes with candida albicans corneal will be self-healing without any antifungal medicine. 2. The relationship has been found between the rehabilitation of candida albicans corneal and the corneal neovascularization. |
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