Clinical Evidences Evaluation About Liver Excess And Kidney Deficiency In Essential Hypertension Based On Systematic Review

Objective:To evaluate the efficacy and safety of essential hypertension treated in light of the pathogenesis theory of "Liver Excess and Kidney Deficiency". Methods: A high sensitive retrieval strategy was adopted for literatures of clinical controlled trial in essential hypertension treated according to"Liver Excess and Kidney Deficiency"in the 20 years. The electronic retrieval databases included:â‘ Chinese Journal Full-text Database;â‘¡Vip Chinese Periodical Database;â‘¢Wan fang Digitized Journal Database.â‘£Chinese Biomedical Literature Database. Seventeen TCM journals not included in databases were searched manually. By means of Rev Man 4.2 software, the overall effect of results from multiple studies was analyzed by Meta-analysis. Meanwhile, a sensitivity analysis was also done. A funnel plot was applied to analyze the publication bias. Results: 2523 clinical research literature on essential hypertension treated according to"Liver Excess and Kidney Deficiency"was retrieved . Eliminate 2305 obvious literature, according to cited literature, collect original literatures 218. 137 unqualified literatures were eliminated for not randomized controlled study, object of study is not tallying, the control group is not essential, experiment method is not tallying, and so on. There were 81 studies were included finally. Twelve trials scored greater than or equal 3 were high quality literatures, while the rest of literatures were low-quality. All the researches are completed in China, both the standard of diagnosis and the Treatment are acknowledged and explicit. The statistical analytical results display that treated in light of the pathogenesis theory of "Liver Excess and Kidney Deficiency"were safe and effective, and the results analyzed by Meta-analysis were stable and reliable. The funnel plot point out that there maybe publication bias. Conclusion: By the Meta-analysis of essential hypertension Treated by Traditional Chinese Medicine indicate that treated in light of the pathogenesis theory of "Liver Excess and Kidney Deficiency"were effective, combined with Western medicine can improve clinical symptoms and increase the total effective rate of the patients . Adverse reaction or dangerous event were less happened, the level of safety is reliable. So the mechanism of "Liver Excess and Kidney Deficiency" in essential hypertension was scientific, essential hypertension treated by Traditional Chinese Medicine should according to the pathogenesis theory of "Liver Excess and Kidney Deficiency"by stages. But further confirmation with clinical randomized controlled trials of high quality, large sample and long-term follow-up is needed.