| ObjectiveTo observe the effect of percutaneous coronary intervention(PCI) on left ventricular regional systolic function in patients with acute myocardial infarction (AMI) by using speckle tracking imaging and two-dimensional echocardiography. And evaluate the in-hospital effect of PCI on patients with AMI.MethodsThirty patients with AMI underwent PCI, and left ventricular long,short axis and apex aspect images were acquireed at baseline before PCI, 3～7 days and 3 months after PCI. Two-dimensional echocardiography and Simpson's method was used to measure LVDS,LVDD,LVESV,LVEDV and LVEF. STI was used to detect the systolic strain parameters of infarction: peak longitudinal,radial,circumferential strain (LSpeak,RSpeak,CSpeak) and the time to peak strain (TPSLS,TPSRS,TPSCS); peak basal and apical rotation (Ptw base,Ptw apex) and the time to peak strain (TPtw base,TPtw apex); peak left ventricular twist and the time to peak strain (Ptw,TPtw) were calculated. Thirty healthy controls were enrolled, and a comparative analysis was done.Results1,There were 213 segments infarction in patients with AMI, 195 segments were successfully obtained by two-dimensional speckle tracking technology strain. 2,LVDS,LVDD,LVESV,LVEDV in AMI patients were all larger than healthy controls and LVEF was smaller than them(all P<0.05); all the indexes had no significant differences at 3～7 days after PCI (P>0.05). With the improving of left ventricular wall motion, LVDS,LVDD,LVESV,LVEDV at 3 months after PCI were all smaller than those at baseline and 3～7 days after PCI; and LVEF rised (all P<0.05).3,Compared with those of healthy controls, LSpeak,RSpeak,CSpeak decreased in each infarct stage in AMI patients and TPSLS,TPSRS,TPSCS retarded (all P<0.05); Compared with the baseline, LSpeak,RSpeak,CSpeak increased in each infarct stage in AMI patients and TPSLS,TPSRS,TPSCS accelerated at 3～7 days after PCI (all P<0.05), and the indexes changed more obviously at 3 months after PCI (all P<0.05).4,Compared with those of healthy controls, Ptw base,Ptw apex,Ptw in each infarct stage in AMI patients were all smaller than them and TPtw base,TPtw apex,TPtw retarded (all P<0.05);Compared with the baseline, Ptw base,Ptw apex and TPtw base,TPtw apex ; Ptw and TPtw were not significantly different at 3～7 days after PCI (P>0.05). With the extension of reperfusion, Ptw base,Ptw apex and Ptw at 3 months after PCI were all larger than those at baseline and 3～7 days after PCI; TPtw base,TPtw apex and TPtw accelerated (all P<0.05).Conclusions1,Left ventricular regional systolic function damaged because of myo-cardial ischemia in patients with acute myocardial infarction.2,With the recovering of myocardial ischemia, PCI can perfect the left ventricular regional systolic function in AMI patients, and with time going, the improvement becomes obviously.3,STI can measure the two-dimensional strain of left ventricular segment and evaluate regional wall motion abnormalities accurately. It provides a non-invasive new method for clinical evaluation of left ventricular regional systolic function in patients with acute myocardial infarction.
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