Analysis Between The Intima-Media Thickness Of The Lower Peripheral Arteries, Shear Rate And Related Factors In Diabetic Patients

Objective:To investigate the relevance between intima-media thickness (IMT) of the lower peripheral arteries, shear rate (SR) and related factors in TypeⅡdiabetic patients. And propose new standpoint and theoretical foundation to diabetic patients for the prevention and therapy.Methods:A total of 108 random TypeⅡdiabetic patients and 57 control groups were recruited for the investigation. The TypeⅡdiabetic patients were divided into two groups:67 patients with thickening Intima and 41 patients with normal Intima. Following factors will be observed at the same time:common femoral artery, superficial femoral artery, popliteal artery, arterial tibial anterior, posterior tibial artery and dorsal pedis artery of double legs with all patients. The intima-media thickness, diameter (D) and PSV (Peak Systole Velocity) of the lower peripheral arteries were measured with CDFI (Color Doppler Flow Imaging), and this data will be used to calculate SR (Shear Rate)-. Meanwhile, observe the condition of plaques, color flow and spectrum shape. Analyze the relationship of lower peripheral arteries judged by Doppler ultrasonic, biochemical parameters and detailed physical examination of the three groups that were used for this investigation.Results:1. In diabetes patients groups, the SR was lower than that are in control group (P＜0.05).2.The risk factors related to the lower peripheral arteries of diabetic patients included years of disease, ages, the fasting plasma glucose,2hour-fasting blood glucose,HbAlc, total cholesterol, triglyceride. high density lipoprotein, low density lipoprotein, whole blood viscosity at high shear rate, fibrinogen, systolic blood pressure, and waist (P＜0.05).3. There is a close relation between MS (Metabolic Syndrome) and lower peripheral arteries of diabetic patients. Conclusion:1. The decrease of SR in diabetes patients can be found before the IMT thicker, and it is one of the important factors that lead to atherosclerosis.2.The lower peripheral arteries of diabetic patient was related to various risk factors of metabolic syndrome, should be early prevented and paid more attention.