Clinical Features And Preliminary Factors Study Of Feeding Intolerance In Preterm Infants

Objective: To study the clinical features and preliminary factors of feeding intolerance in preterm infants, in order to provide the clinicalsupport for preventing feeding intolerance in preterm infants. Methods: Retrospective checking the 1159 cases of preterm infants had been treated in the Neonatology of the First Affiliated Hospital of Xinjiang Medical University from January 2007 to December 2009. They are stratified by year and random sampled.In accordance with inclusion and exclusion criteria,716 cases were analysis in the study. To descripe the clinical features, inference and Logistic regression analysis of the possible factor of feeding intolerance in preterm infants. Results:①The incidence of feeding intolerance in preterm infants was 27.6%, and that of the very low birth weight neonates are up to 76.4%; Gastric retention is the oniy highest clinical feature of feeding intolerance in preterm infants(47.2%).②Feeding intolerance in preterm infants focus on the period after being born and feed within three day.③Compared with the feeding tolerance group, the feeding intolerance group is statistical difference in gestational age (t=-6.299, P<0.05), birth weight (t=-8.892, P<0.05), but is no statistical difference in gender (χ2=0.128, P=0.720), maternal age, (t=0.795, P= 0.427), ethnic(χ2=1.318, P=0.858). With increasing gestational age, increasing birth weight, the rate of feeding intolerance in preterm infants is lower, showing a dose-response relationship.④Binary Logistic regression analysis shows that birth weight (β=-0.011, P<0.05, Exp(β)= 0.979) is a protective factor, but open milk time (β=0.149, P <0.05, Exp (β)= 1.160), meconium discharge time (β=0.019, P<0.05, Exp (β)= 1.020), diseases of preterm infants (β=0.229, P<0.05, Exp (β)= 1.257) and mechanical ventilation using (β=1.319, P<0.05, Exp (β)= 3.739) are the risk factors. Conclusion: The feeding intolerance of preterm infants are the clinical syndromes and has the high incidence, the occurrence of time to focus on the three day after being born and after feeding, clinical manifestation, birth weight is a protective factor, open milk time, meconium discharge time, disease in preterm infants and mechanical ventilation using are the risk factors, prevention and intervention are necessary.