Multivariate Analysis For Prognostic Factors Of 37 Chondrosarcoma Patients

Objective:To explore the prognostic factors of chondrosarcoma for survival.Methods:we retrospectively reviewed the clinical data of 37 chondrosarcoma patients between 2005.12～2008.3. Patient's gender, age. tumor site, course of symptoms. Enneking surgical stage, type of surgery, distant metastasis and local recurrence were analyzed by Kaplan-Meier method. Log-rank test and COX regression model.The numeration data was analyzed by X2-or Fisher exact test.Results:37 patients had at least 3 years follow up.26 patients were alive and 15 patients died. Live time was between 3 to 63 months with a mean of 39.2 months and the median survival was 42 months. Overall survival rate of three years was 70.3 %. Univariate analysis revealed that the prognosis of chondrosarcoma was significantly related to Enneking surgical stage (p＜0.001). type of surgery (p＜0.001) and distant metastasis (p＜0.001). Multivariate analysis by COX regression model suggested Enneking surgical stage (p=0.007). type of surgery (p=0.01) were the independent prognostic factors while distant metastasis was not (p=0.942).Conclusion:This trial indicated that only Enneking surgical stage and type of surgery were shown to be independent predictors of prognosis of chondrosarcoma. The higher Enneking surgical stage is. the poorer the outcome is. The complete resection can provide a better survival rate than incomplete.