The Clinical Value Of Color Doppler Ultrasonography In Assessing Curative Effect Of Neoadjuvant Chemotherapy For Breast Cancer

Objective Through exploring the changes of the morphology, blood mode and RI value in the primary lesions and axillary lymph nodes before and after NCT, the clinical value of CDFI and PDI are investigated in assessing curative effect of NCT in breast cancer treatment.Methods The primary lesions and axillary lymph nodes of the selected 67 patients with breast cancer were examined by Doppler ultrasound before and after NCT. All of the sonographical examinations were performed by the same operator with direct contact before NCT and within 48h after NCT. The primary lesions were observed at several sections, including its size, shape, edge, surrounding halo, internal echo and rear echo. Then the hemodynamics parameters were acquired, such as PSV, RI and etc. The axillary lymph nodes were examined, including its size, shape, internal echo and blood mode. Clinical evaluation followed the standard of RECIST, pathological evaluation adopted the classification method of Miller&Payne. The statistical analyses of above data were conducted with the statistical software package SPSS 10.0.Results There are 37 effective cases (55.22%) according to pathological evaluation. Seven cases with complete release, 44 cases with partial release, 14 cases without significant change and 2 cases with progressing lesions were revealed by palpation. Five cases with vanlish lesion, 40 cases with reducing lesion, 19 cases with unchangeable lesion and 3 cases with increasing size of lesion were showed under ultrasonographic observation. To sum up, it was effective to 67.16% patients. In CDFI and PDI examination:⑴53 cases (79.10%) with decreasing blood mode was uncovered with CDFI after treatment, and 57 cases (85.07%) in PDI examination.⑵70.15% cases were effective with drop of PSV in PDI observation.⑶64.18% cases were effective according to the reducing RI value.⑷changes of 71.64% axillary metastasis lymph nodes were found such as reducing in volume and decreasing of color Doppler signals.⑸If assessing with the size of lesion and RI value at the same time in ultrasonographic, the effective cases are only 18 (26.87%).Conclusions 1. CDFI is highly consistent with pathological evaluation at the size of lesion to evaluate the curative effect of NCT.2. The effectiveness rate based on RI value which is acquired from CDFI is close to that from pathological evaluation,.3. The method of combining the size and RI value of lesions in CFDI examination is superior to those methods which employ one single parameter. Furthermore this comprehensive approach has great clinical significance in assessing curative effect of NCT.