| Objective:To investigate the changes in neuron-specific enolase(NSE) and S100B in acute brain injury patient's serum before and after using propofol, simultaneously, to investigate the changes in neuron-specific enolase(NSE) and S100B in patient's serum without using propofol, through theses changes evaluates the neuroprotective effects of the propofol.Methods:24 patients with acute brain injury, and GCS score≤12 points and into the ICU within 12 hours after injury, were randomly divided into propofol group (A group, n= 12) and control group (B group, n= 12), A group using propofol with lmg/kg/h speed pumped in (continued use 24h), serum NSE and S100B were measured by ECLIA in patients 12h after injury,24h after injury,48h injury,72h after injury. A group patient's heart rate, respiration rate, blood pressure, blood oxygen saturation,WBC content and neutral granulocyte content were recorded before and after treatment. B group using saline as a control, serum NSE and S100B were same measured by ECLIA in patients 12h after injury, 24h after injury,48h injury,72h after injury.Results:Serum concentrations of NSE and S100B were significantly lower in the the propofol group compared with that in the control group, respectively, at 24h after injury,48h after injury,72h after injury. The patient's heart rate, respiration rate, blood pressure, blood oxygen saturation,WBC content and neutral granulocyte content weren't had significant difference.Conclusion:The application of propofol by intravenous-pumping might suppress the increase of NSE and S100B in acute brain injury patient's serum, attenuate the secondary cerebral injury, and exert a protective influence on the brain, without adverse reaction. |
