Correlation Analysis Between Serum Neuron-specific Enolase And The Detection Of Gene Mutations In Lung Adenocarcinoma

Background: Lung cancer is a chronic,progressive and malignant disease associated with ever-growing incidence and mortality.Targeted therapy plays an important role in the clinical treatment of lung cancer.Besides,neuron-specific enolase(NSE),an intracellular enzyme,is highly correlated with the targeted treatment outcome in patients with non-small cell lung cancer(NSCLC).The present study aimed to explore the correlation of NSE with the detection of gene mutations.Methods: It is a case-control study.From June 2017 to October 2019,the newly diagnosed patients with lung adenocarcinoma were enrolled from the First Affiliated Hospital of Anhui Medical University.Next generation sequencing(NGS)was conducted in these patients.Kruskal-Wallis test was used to calculate the difference in NSE levels between mutant and non-mutant group and the differences were compared between blood and tissue samples.Results: Compared with patients with no gene mutation(15.4±7.8 mmol/L),the NSE levels in patients with gene mutations were remarkably increased in blood sample group(22.2±12.9 mmol/L)(P<0.05).Besides,the linear regression model was applied for analysis which further emphasized the close relationship between them.The area under the ROC curve(AUC)of NSE was 0.7300 [95% confidence interval(CI):0.6059–0.8541]and optimal threshold was 18.5650 U/m L with a sensitivity of 87.50%and a specificity of 52.08%.In addition,NSE levels increased in blood sample group,suggesting that the occurrence of polygenic mutation with dismal prognosis,but no correlation was detected in tissue sample group.Conclusions: This study elucidates the functional role of NSE,and findings in this study notably increase the gene detection efficiency for lung adenocarcinoma.