The Study Of Clinical Features And Relative Factors In The Pathogenesis Of The Recent Peptic Ulcer

Objective:To explore the clinical characteristics and the main relative factors of the recent peptic ulcer, and provide preventive measures to cure peptic ulcer on a scientific basis.Methods:This paper adopts a hospital-based case-control study method. Based on the uniform inclusion and exclusion criteria, the case group consists of patients who are randomly-selected new cases of peptic ulcer confirmed by the Gastro-Endoscopic Room of the Second Xiangya Hospital from May 1,2010 to November 1,2010, while the control group is made up of randomly-selected patients suffering from non-atrophic gastritis confirmed by the Gastro-Endoscopic Room of the same hospital. A questionnaire survey has been conducted among those subjects, concerning their general physical conditions, living habits, dietary habits, medical history and clinical symptoms ect.Results:This questionnaire survey has peptic ulcer patients 253,the number of male patients is 182,and female 71, this questionnaire survey has has non-atrophic gastritis 125, the number of male patients is 72,and female 53.In the peptic ulcer group,male patients' to female patients' ratio of 2010 group is 2.6:1.37.5% of the patients are under the age of 40, and 29.7% of them are between the age of 41 and 50, while 22.9% of them are between the age of 51 and 60, and 9.9% of the patients are over 60. the main clinical manifestation is regular abdominal pain; Patients' visiting time is still concentrated in the active period。The analysis of factors related to PU:1. Univariate analysis results showed:gender secondary education, engaged in manual occupations, living without the law, smoking, drinking Wine, lack of sleep, irregular diet, consumption of milk, consumption of coffee, consumption of fried foods, A history of cardiovascular disease and the pathogenesis of PU (P< 0.05); and age, the staple food types, edible nuts, pepper, a history of autoimmune disease were not related with the incidence of PU (P>0.05) 2.Multivariate logistic regression analysis results showed that:irregular lifestyle, smoking,lack of sleep time,eating disorders, consumption of fried foods, cardiovascular disease history are risk factors for peptic ulcer (OR>1); consumption of milk are the protective factors of peptic ulcer disease(OR<1).Conclusions:The characteristics of the illness and clinical symptoms of peptic ulcer is the incidence rate for male patients is higher than female patients, and they are mainly young and middle-aged, and their clinical manifestations is the rule pain; and thier treatment time is mainly in the active phase。In the case-control study, univariate analysis results showed that the factors related to peptic ulcer disease include the male gender, secondary education background, being engaged in manual labor occupations, irregular lifestyle, smoking, drinking, irregular eating habits, consumption of coffee, fried food, and the history of cardiovascular disease, while plenty sleep and the consumption of milk have some effects on avoiding the occurrence of peptic ulcer. Multivariate analysis results showed that irregular lifestyle, smoking, irregular eating habits, consumption of milk, eating fried food, the amount of sleep, and the history of cardiovascular disease are all associated with the pathogenesis of PU.