Study Of The Increase Of Decrease Of Atractylodes Macrocephala Koidz Laminated Simu Tonga Treat Diabetic Macular Edema

Background Diabetic retinopathy(DR) is one of the main complications of diabetes mellitus, and diabetic macular edema(DME), one of the causes of diabetic retinopathy, is considered as the major damage to vision, which seriously affects the quality of survival and is still the main reason of visually impaired in the next few years. The exact DME pathogenesis is not completely understood, and DME treatment research focuses on the eye local, such as glass gut injection corticosteroids or/and anti-VEGF or PKC inhibitor and vitreous incision cataract, furthermore, it exists certain controversial in its long curative effect and safety. The research on DME TCM therapy is not much as well as mostly lacks the quantitative indexes of the thickness and total volume of macular retina, so it relies mainly on fundus fluorescein angiography(FFA) to judge the changes of the macular edema.Objective The thesis studies the increase or decrease of atractylodes macrocephala koidz laminated simu tonga as the treatment of the patient been diagnosed with DME, and Zeiss Stratus OCT-3000 as DME qualitative and quantitative means of inspection, at the same time, acquires the related risk factors value for the patient such as blood pressure, blood triglycerides and fasting glucose, and then analyzes the changes result of macular edema with the SPSS13.0 statistics software to explore DME therapeutic effect due to the increase or decrease of atractylodes macrocephala koidz fits siwu tonga and further analyzes its possible mechanism.Subject and Method The thesis collects diabetic macular edema 45 patients(84 eyes),randomly divided into observation group(25patients 48eyes) and control group(20patients 36eyes), from Anhui Provincial Hospital Ophthalmology affiliated to Medical University of Anhui and Anhui Traditional Chinese Medicine Hospital Ophthalmology, and records the age, gender, patient course, stages, fasting blood glucose, blood pressure, blood triglyceride, retinal average thickness and macular total volume among 1mm diameter around macular centre, etc. The control group is given foundation treatment, which is formal falling blood sugar, blood pressure and thematic fat treatment by physicians, and the observation group is given foundation treatment as well as internal treatment. the base method of TCM as follows: ginseng 20g, white atractylodes 10g, tuckahoe 10g, alisma orientalis 10g, lotus seed, 30g YiRen meat 10g, angelica 10g,xiong 10g, safflower 10g officinale, 10g, sand benevolence 10g, balloonflower 10g. According to patient's pulse condition, diet and sleep, physical strength, it may increase and decrease. The method to take: one agent per day, fry to liquid and then take juice 200ml,twice to take,15 days for one period of treatment, and take three treatment. Both groups start to be visited after treatment 1 month and 3 months follow-up,start ,in order to observe macular edema and vision changes.Results The normal information of the selected cases from the trial and control grom is not statistically different and is comparable, P>0.05, the information includes age, gender, DR duration, DR installment, systolic blood pressure, fasting blood glucose, blood triglyceride. compared with former treatment ,fasting blood glucose,systolic blood pressure and blood triglyceride of both groups have dropped, by t-test, P>0.05, and there are not statistical differences. Vision changes of both are not statistically different P>0.05,and average thickness changes in macular center 1mm retina are not statistically different compared with former treatment between groups, P>0.05.Macular total volume changes of both group are the same as vision changes. Three months after treatment of the two groups, fasting glucose, systolic blood pressure and blood triglyceride of both are not significantly lower compared before by t-test, P > 0.05, there are not statistical differences; and there are not statistical differences between the groups, P>0.05.vision changes are statistical differences between the groups, P<0.05, and the observation group is better than the control one.the diminution in average thickness of macular center 1mm retina in the observation group are statistically different than before, P<0.05, and there are significantly statistical differences between the groups, P<0.01.the diminution of macular total volume in the observation group are statistically different than before, P<0.05, and there are significantly statistical differences between the groups, P<0.01.Conclusion With the balanced control of blood sugar, blood pressure and blood triglyceride, the increase and decrease of atractylodes macrocephala koidz laminated siwu tonga can delay the DME declining eyesight, and there are statistical differences between the groups(P<0.05). After three treatment, Macular edema may disappear, and average thickness of macular centre 1mm retina and macular total volume are statistically different than before the treatment (P<0.05), and there are statistical differences between the groups(P<0.01).