| Background In recent years, by the unremitting efforts of several generations, Medical science and technology are rapidly developing. the equipment and technology of radiofrequency catheter ablation has Appeared the contending situation and has brought a bright future for the treatment of complex arrhythmias ,especially for atrial fibrillation treatment. And has brought the dawn of Cardiac electrophysiology physicians and patients with atrial fibrillation. And in recent years, high sensitive C-reactive protein (hs-CRP) and serum cardiac troponin I (cTnI) in field of cardiovascular disease has become a hot research ,but lessresearchhasbeendown on the relationship between hs- CRP and atrial fibrillation and whethere cTnI correlates with the injury of cardiae musele in Patients undergoing RFCA(radiofrequency Catheter ablation). Radiofrequency catheter ablation of atrial fibrillation as a new treatment ofatrial fibrillation, the high recurrence has been the supreme problem.Therefore, it is significance to discuss the predictive factors of recurrence of atrial fibrillation after catheterablation.Objective To discuss clinical value of high sensitive C-reactive protein(hs-CRP) levelsand cardiac troponin I (cTnI) levels in Predicting early the recurrence of Atrial Fibrillation(AF) after radiofrequency ablation guided by EnSite-Array non-contact three-dimensional mapping system .Methods To analyze retrospectively the clinieal data of 48 Patients with atrial fibrillation who consequently underwen radiofrequency catheter ablation guided by three-dimensional mapping system (EnSite-Array non-contact mapping) from January 2009 to December 2010 in the First People's Hospital of Jining City.Aecording to radiofrequency ablation guided by three-dimensional mapping system (EnSite-Array non-contact mapping),we divided into preoperative groups and postoperative groups.Aecording to the the symptoms,12-Leads ECG and Holter ECG and other indicators of the Patients after three months, we divided all the Patients into two group s-success group (38 cases) and recurrence group (10 cases).We Repeatedly Measure hs-CRP concentrations by Immunoturbidimetry in 12-24 hours before surgery and after 4 hours,and Repeatedly Measure cTnI concentrations by Biosite -Triage dry and rapid and quantitative myocardial infarction/heart failure diagnostic apparatus (U.S. Biosite products) in 12-24 hours before surgery and after 4 hours.Cardiac troponin I (cTnI) normal range<0.40ng/mL.The definition of early recurrence:Within three months,symptomatic atrial fibrillation has occurredor asymptomatic atrial fibrillation of duration>10min has been recorded after surgery.Results 10 cases of 48 Patients occurred recurrence.6cases of 34 paroxysmal atrial fibrillation occurred recurrence. 4 cases of 14 persistent atrial fibrillation recurrence occurred recurrence. Successful group and relapse group have no obviously difference in age, gender, medical history, with the disease, ejection fraction,type of atrial fibrillation,left atrial size, etc.(P>0.05).Through radiofrequency ablation guided by three-dimensional mapping system (EnSite-Array non-contact mapping), hs-CRP levels (21.39±14.27mg/L) and troponin I levels (1.82±0.53ng/ml) of postoperative groups obviously more than hs-CRP levels (3.23±1.13mg/L) and troponin I levels (0.03±0.01ng/ml) of preoperative groups(P<0.001).Postoperative high sensitive C-reactive protein (hs-CRP) concentration changes in the value (12.37±4.37mg/ml)of of The success group (A group) and postoperative hs-CRP concentration changes in the value (40.28±13.96mg/ml ) of the relapse group (B group) compared,there were significant differences between the two(P<0.001). Postoperative troponin I (cTnI) concentration changes in the value (1.79±0.53ng/ml) of the success group (Agroup)and postoperative troponin I (cTnI) concentration change value (1.83±0.55ng/ml)of the relapse group (B) compared,there were no significant statistical difference between the two (P> 0.05).Conclusion Through radiofrequency ablation guided by three-dimensional mapping system (EnSite-Array non-contact mapping),the patient will be subject to different degrees myocardialdamage and postoperative early period (after 3 months) have a certain recurrence rate.hs-CRP is closely related with atrial fibrillation,hs-CRP concentrations may be involved in the occurrence and development of atrial fibrillation, and have some predictive value in evaluating early recurrence of atrial fibrillation after Radiofrequency catheter ablation. But the cardiac troponin concentrations (cTnI) changes have no predictive value in evaluating early recurrence of atrial fibrillation after Radiofrequency catheter ablation.
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