| Objectives":Using the EBM method to evaluate the efficiency and safty of the treatment of diabetic kidney disease by tonifing kidney and nourishing qi and activating blood or combining with ACEI/ARB.To review systematically whether there are enough existing evidences that the treatment of diabetic kidney disease by tonifing kidney and nourishing qi and activating blood.Methods:Cochrane Controlled Trials Register (CCTR),PubMed,Embase and Chinese Biological Medicine database(CBM),China National Knowledge Infrastructure (CNKI)WeiPu data(VIP) and WanFang data were widely referred.More than 10 Chinese core journals related to TCM during 2010 were also searched by hand.Two authors independently assessed trial qualities and extracted data from these Randomized Controlled Trails, then imported them into the Meta-analysis by Rev.Man 4.2.2.Results:19 azstudies (1669 patients) were identified.The results of Meta-analysis indicated:there are evidences to support that the treatment of diabetic kidney disease by tonifing kidney and nourishing qi and activating blood or combining with ACEI/ARB is better than ACEI/ARB treatment only on symptom physical sign,blood glucose,blood-fat,hemorheology and decreasing the urine albumin excretion rate(UAER) and 24h urine protein,decreasingthe level of serum creatinine and urea nitrogen. However,the methododlogical quality is considered low in these stulevels of prevention.Conclusions:Based on the aforementioned results, conclusions could be drawn that the treatment of diabetic kidney disease by tonifing kidney and nourishing qi and activating blood or combining with ACEI/ARB can improve the clinical efficacy.However,the evidence is not enough strong because of the low qualities of trials, the small sample sizes in some researches and not long enough treatment and follow-up time.Therefore,these results should be interpreted with caution.The exact effect need to design a strict multi-center, large sample randomized controlled trials further confirmed.
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