The Investigation For Clinical Efficacy Of Splenectomy In Some Hematological Diseases

Objective:Analyzing the therapeutic efficacy of splenectomy in patients suffering from a part of hematological diseases and investigating the factors which may affect the response to splenectomy for ITP to provide the idea for clicinal therapy.Method:We collected and analyzed the clinical and followed up information of 61 cases with hematological diseases who underwent splenectomy between 2004 and 2010 in our hospital, compared the preoperative with postoperative ,follow-up hematological information in idiopathic thrombocytopenic purpura ( ITP ) , hereditary spherocytosis ( HS ) , Mediterranean anemia patients and made the univariate analysis for sex,age, duration of disease, preoperative platelet counts,the peak of postoperative platelet counts within the first week, steroid response by using SPSS soft, which may predict the response to splenectomy for ITP. We also compared the preoperative with postoperative,follow-up information in Evans syndrome,myelofibrosis(MF),Lymphoma and Chronic lymphocytic leukemia (CLL) patients.Results:1.clinical efficacy:We could get the results from the 61 patients by comparing preoperative with postoperative,follow-up information.The effective rates of splenectomy for ITP patients,HS and Mediterranean anemia patients who were followed up more than 1 year were 75%,88.89%,100%.The efficacy of splenectomy for Evans syndrome patients is significant whose Medical treatment was ineffective. splenectomy also could relive the symptoms about Splenomegaly and Hypersplenism of some malignant hematological diseases such as MF, Lymphoma and CLL.2. Monofactor analysis of prognosis for ITP:Sex,duration of disease, preoperative platelet counts,the peak of postoperative platelet counts within the first week,steroid response were not statistical significanct(P<0.05)between the effective splenectomy group and ineffective splenectomy group.The age may predict the the respone to splenectomy for ITP. The younger age is, the better efficacy of splenectomy is.Conclusions:The efficacy of splenectomy for some hematological diseases is significanct. The age may predict the the respone to splenectomy for ITP. The younger age is, the better efficacy of splenectomy is.