The Correlation Of Carotid Intima-media Thickness On The Severity Of Femoral Popliteal Arteriosclerosis Obliterans

Objective: By investigating the relativity of carotid intima-media thickness (CIMT), ankle-brachial index (ABI) and risk factors on the severity of 151 hospitalized patients with femoral popliteal arteriosclerosis obliterans (ASO),to provide a certain basis for the etiological research of emoral popliteal arteriosclerosis obliterans,and its primary & secondary prevention,as well as the clinically target-oriented treatment.Methods: The objects of present study were selected from patients with lower extremity arteriosclerosis obliterans,who were consecutively admitted to the division of vascular surgery in first affiliated hospital Fujian medical university from March 2007 to October 2010. After collecting their clinical information such as gender, age, blood lipid profile, fasting blood glucose (FBG), hepatic function, renal function, C-reactive protein (CRP), homocysteine (HCY), glomerular filtration rate (GFR), fibrinogen (FIB),CIMT value, ABI value,and the history of hypertension, diabetes mellitus (DM), dyslipidemia, coronary heart disease, cerebral infarction, and smoking et al,we chose 151 patients whose data was complete, which have been proved femoral popliteal arteriosclerosis arteriosclerosis obliterans by digital subtraction angiography of lower extremity. According to TASC classification of femoral popliteal lesions, all subjects were divided into three groups based on the severity of emoral popliteal arteriosclerosis obliterans. Chi Square Test, One-Way ANOVA or Spearman Rank Correlation were used to compare among the three groups the proportion of male and female, smoker,the prevalence rate of hypertension, DM, dyslipidemia, coronary heart disease and cerebral infarction, age, smoking index, serum total cholesterol(TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), CRP, HCY, GFR, total bilirubin(TBIL), uric acid(UA), FBG, FIB, CIMT value and ABI value. Results:1. Of alI the 151 cases, there are 127 cases were found to have increased CIMT (84.10%).2. The severity of femoral popliteal ASO was positively related to CIMT value, age and renal failure (P<0.001, 0.003, 0.002), and their correlation coefficient were 0.371, 0.244, 0.254, respectively. But, The severity of femoral popliteal ASO was negatively related to GFR and ABI value (P<0.001, 0.001), and their correlation coefficient were -0.528,-0.296, respectively.3. The differences of TG, CRP, UA, FIB and the prevalence rate of hypertension were statistically significant. Among the three groups,these variables were given P values of 0.026, 0.006, 0.034, 0.029, 0.002, respectively.4. There were no significant differences in gender, TC, LDL-C, HCY, TBIL, FBG, smoking index, the prevalence rate of DM, dyslipidemia, coronary heart disease, cerebral infarction and the proportion of smoker among the three groups.Conclusion:1. There is often a high rate of increased CIMT found in patients with femoral popliteal ASO (84.10%). It is clear that increased CIMT are often found in severer femoral popliteal ASO. The result indicated that an increased CIMT was associated with severer femoral popliteal ASO. The odd ratio of the severity of femoral popliteal ASO was 9.4 per 0.1mm CIMT difference.2. The patients with elder age, the severer femoral popliteal ASO. The odd ratio of the severity of femoral popliteal ASO was 1.7 per 10 years difference.3. Hypertension,hypertriglyceridemia, hyperfiberinogenemia, higher uric acid and C-reactive protein level are often found in severer femoral popliteal ASO.4. The severer femoral popliteal ASO, the lower the GFR value and severer renal failure.5. The severer femoral popliteal ASO, the lower theABI value.