Patients With Amyotrophic Lateral Sclerosis Assessment And The Preliminary Study Of Jian Pi Yi Fei Fang To Amyotrophic Lateral Sclerosis's Swallowing Function

Research backgroundAmyotrophic lateral sclerosis is a reason not clear violation of the spinal cord anterior horn cells selective, brainstem motor nuclei and posterior pyramidal tract progressive, fatal neurodegenerative diseases, Its pathogenesis is not yet clear, Western lack of effects of therapy. Involvement is a common symptom of swallowing function, patients can lead to dehydration, nutritional disorders, and even then Erzhi aspiration pneumonia aspiration, ultimately complicated by respiratory muscle paralysis or respiratory death. Appropriate for evaluation of swallowing function in patients with ALS can help early detection of swallowing dysfunction and to guide clinical treatment, but few clinical studies of the disease at home and abroad, for its lack of a systematic summary of characteristics of swallowing function. In recent years, Chinese medicine treatment of ALS has achieved a certain effect, and actively explore the medical tracking the effects of treatment of the disease in order to form a standardized system of traditional Chinese medicine diagnosis and treatment for clinical treatment of the corresponding objective basis for guidance.Research objectiveOn swallowing function in patients with ALS were determined using Jian pi yi fei fang Treatment of ALS patients and ALS functional score with internationally accepted scale for assessment, observation of the patients were evaluated before and after taking the Jian pi yi fei fang ALS Treatment of changes in swallowing function of patients, for clinical assessment and treatment of the disease play a Chinese advantage to provide an objective basis and guidance.Research methodPatients met the inclusion criteria will.be included in the study, through a common international Kubota drinking water test, ALSFRS Scale, ALSSS Scale, Frenchay dysarthria assessment method, dysphagia severity score (VGF), Swallowing and other imaging records of the table, the use of forward-looking research methods, giving Jian pi yi fei fang prescription treatment for 5 months Patients before treatment and after treatment assessment of swallowing function once a month, using SPSS13.0 Statistics Package survey data entry, verification and statistical analysis.Research resultsIncluded 22 cases of amyotrophic lateral sclerosis,2 patients lost, a routine PEG,2 patients had end point events, male to female ratio 2.3:1, age of onset was 56.40±10.64 years.1.20 cases of ALS patients found that ALS patients with swallowing contrast to oral and pharyngeal phase of mild to moderate damage to the main oral manifestations of dysfunction of the main food for the oral vestibule residues, bolus transfer damage to the base of the tongue; pharyngeal dysfunction, mainly of for the transfer of the bolus to the pharynx, the throat passage of the epiglottis Valley food residues, food residues piriform recess injury, but in 20 cases of ALS patients does not appear on the abnormal lower esophageal sphincter, esophageal sphincter function in patients with ALS that remained normal.2.20 cases of ALS patients treated with Jian pi yi fei fang, and was before the treatment after one month, two months, three months, four months, five months, patients with oral and pharyngeal phase of mild to moderate damage to the main application of repeated measures analysis of variance test showed that ALS patients before and after taking the Treatment of Jian pi yi fei fang ALSFRS-R scale, ALSSS scale, Kubota drinking water test score difference was statistically significant (P< 0.05), ALSFRS-R scale down the value of the monthly general decreasing trend, Frenchay scale scores no significant changes before and after treatment.Conclusion1. The group of 20 patients with amyotrophic lateral sclerosis ALS patients with swallowing disorders showed mainly mild to moderate oral cavity and pharynx of the main phase.2. Study found that patients treated with ALS Treatment of Jian pi yi fei fang after 5 months, Although the patients condition still in progress, but to some extent, delayed the patient feeding, dressing, writing, bed stand, walking and other motor function and speech, salivation, swallowing, breathing and other symptoms pace of progress in the medulla oblongata.