Rhubarb Capsule On Acute Kidney Injury In Critically Ill Patients With Early Disease Intervention Clinical Study

BackgroundAcute kidney injury is a rapid decline in glomerular filtration rate, characterized by the clinical syndrome, is a serious threat to the lives of patients with common diseases and high mortality. Although the clinical acute kidney injury has been widely appreciated, treatment has made great progress, but the lack of textbooks and literature in a unified diagnostic criteria, resulting in delays in diagnosis and treatment. Recent studies have found that cystatin-C in patients with early detection can be used as the indicator of renal function, acute kidney injury it when creatinine rose faster than 1-2 days. In Chinese medicine, the rhubarb a pass in the capture of removing heat and cooling blood line stasis, Qing Xie hot and humid, hemostatic efficacy, so as kidney disease and critical care rhubarb in a popular drug. On this basis, given the intervention of rhubarb capsule, is able to prevent a further decline in renal function or improved renal function, with active clinical significance of early acute kidney injury to provide a treatment.ObjectivePreliminary testing of small samples of rhubarb capsule on acute kidney injury in critically ill patients with early therapeutic intervention, whether it can prevent the occurrence of acute kidney injury or progress in reducing the incidence of complications in patients and reduce patient length of stay, cost and mortality.MethodsRandomized controlled clinical methods used meet the strict inclusion criteria for the diagnosis and 50 patients were randomly divided into treatment group and control group, treatment group (rhubarb capsules plus conventional treatment group) 25 cases,25 cases in control group (conventional drug therapy Group). Dynamics were observed cystatin C, creatinine, glomerular filtration ate, blood urea nitrogen, urine output and the case of TCM, and the case of the above two groups were compared.ResultsIn this study, a total of 2 cases fall off, the 2 cases without statistical analysis. The basis of the two groups before treatment were no significant differences. Early renal damage in patients with Syndrome case, the actual situation mixed with a total of 30 cases,18 cases positive, the actual (?)tuation of the patient inclusion 62.5% of the total patients, patients with positive 37.5% of total patients. The treatment group and the reality mingled syndrome cases and positive cases the percentage is higher than the percentage, but both by chi-square test was no significant difference; the control group and the reality mingled syndrome cases and positive cases is higher than the percentage of a percentage, but both by card Square test no significant difference. Early acute kidney injury in critically ill patients in the actual situation of mixed syndromes more than the proportion of evidence. Treatment group cystatin-C after treatment than before treatment was significantly decreased (P<0.01), compared with the control group (?)gnificantly (P<0.05). After treatment, the treatment group compared with the previous serum creatinine decreased significantly (P<0.01), compared with the control group was statistically significant (P<0.05). After treatment, the glomerular filtration rate significantly higher than before (P<0.01), compared with the control group was statistically significant (P<0.05). Treatment group after treatment than before treatment urea nitrogen was no significant reduction (P> 0.05), compared with the control group, no significant difference (P> 0.05). Two days of hospitalization and mortality compared with no statistical significance (P> 0.05).Adverse events observed in the treatment group 23 cases,2 patients had diarrhea, diarrhea treatment could be given relief, not withdraw from the study. Observation group,3 patients suffered from diarrhea, diarrhea treatment could be given relief, not withdraw from the study.ConclusionRhubarb capsule in treating early acute kidney injury in critically ill patients, can reduce the cystatin-C, serum creatinine, glomerular filtration rate increase to prevent the occurrence of renal failure and or further deterioration, suggesting that the treatment of critically ill patients Rhubarb capsule Patients with early acute kidney injury is a positive.