Clinical Study On The Effect Of Guyi Decoction On Hemorheology In Lower Limb Fracture Earlier Period

Objective To observe the clinical effects of Guyi decoction healing lower limb fracture earlier period on hemorheology, and evaluate the clinical significance of primary treatment of fracture with blood-activating and stasis-dissolving Chinese medicine to ameliorate the hemorheology status.Methods The prospective, randomized, compared clinical trial design method was adopted. From August 2010 to February 2011,90 patients of closed lower limb fracture earlier period with the syndrome of Qi stagnation and blood-stasis were employed to made study in Foshan hospital of traditional Chinese medicine, according to the inclusion criteria and exclusion criteria. According to general conditions such as gender, age, injury site, visiting time,90 cases were divided into experimental group (group A), control group (group B) and blank group (group C) in accordance with the method of stratified randomization at proportion of 1:1:1. Three groups were be cured the same conventional and basic therapy. Simultaneously, group A was treated with Guyi decoction once daily on the 1st to 7th day after therapy; group B was treated with Taohong Siwu decoction once daily on the 1st to 7th day after therapy; and group C was not treated with any Chinese medicine decoction. Test was observed by three groups of objects with change of outcome measures, such as clinical symptom and physical sign scores and the syndrome of Qi stagnation and blood-stasis accumulated points before treatment and on the 1st,4th and 7th day after therapy, curative effect of the syndrome of Qi stagnation and blood-stasis, hemorrheologic outcome before treatment and after therapy, the injured limb deep vein color Doppler ultrasonography, and the safe indices before treatment and after therapy. The data was made with statistical analysis, and the change of outcome measures was compared. Results There were no statistically significant differences in general conditions among the three groups (P>0.05), which suggested that the three groups were comparable. There were no statistically significant differences in clinical symptom and physical sign scores, the syndrome of Qi stagnation and blood-stasis accumulated points, and hemorrheologic outcome among the three groups before treatment (P>0.05), which also suggested that the three groups were comparable. There were statistically significant differences in clinical symptom and physical sign scores, the syndrome of Qi stagnation and blood-stasis accumulated points, and hemorrheologic outcome among the three groups on the 7th day after therapy (P<0.05), which suggested that the clinical effects of Guyi decoction reducing clinical symptom and physical sign scores and the syndrome of Qi stagnation and blood-stasis accumulated points and ameliorating the hemorheology status were the best, followed by Taohong Siwu decoction. There was statistically significant difference in curative effect of the syndrome of Qi stagnation and blood-stasis among the three groups (compared three groups P<0.05, compared pairwise P<0.0167), which suggested that the clinical effects of Guyi decoction healing the syndrome of Qi stagnation and blood-stasis was the best, followed by Taohong Siwu decoction. There was statistically significant difference in the injured limb deep vein color Doppler ultrasonography among the three groups (P<0.05), but there were no statistically significant differences between group A and groups B and between group B and groups C (P>0.0167). There was statistically significant difference between group A and groups C (P<0.0167), which suggested that Guyi decoction played a clinical role in the prevention of the injured limb deep vein color Doppler ultrasonography. There was no statistically significant difference in the safe indices among the three groups (P>0.05), which suggested that Guyi decoction and Taohong Siwu decoction were safe employment.Conclusion The syndrome of Qi stagnation and blood-stasis is the common with lower limb fracture earlier period. Guyi decoction, with appropriate drug selection, reasonable compatibility, effective treatment and safe employment, can reduce clinical symptom and physical sign scores and the syndrome of Qi stagnation and blood-stasis accumulated points, ameliorate the hemorheology status, prevent deep vein thrombosis with lower limb fracture earlier period. It is one of the effective and safe prescriptions in primary treatment of lower limb fracture. Simultaneously, reviewed of the literature, the study finds a correlation between the syndrome of Qi stagnation and blood-stasis and hemorheology, and also finds a intimate correlation between hemorheology and fracture earlier period, which concludes that primary treatment of fracture with blood-activating and stasis-dissolving Chinese medicine to ameliorate the hemorheology status has a very importantly theoretical and practical clinical significance for union of fracture and prevention of deep venous thrombosis.